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MYD88 and rheumatoid arthritis are reported together in 2 articles.
Gene
MYD88
- HGNC
- HGNC:7562
17articles
17mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Rheumatoid arthritis
212articles
212mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Hyaluronic acid microneedle patch for transdermal delivery of naringin-loaded PEGylated terpesomes in a rat model of rheumatoid arthritis: Modulation TGF-β1, oxidative stress, and inflammation.
PMID 41970504 | PMCID PMC13062552 | DOI 10.1016/j.ijpx.2026.100527 · International journal of pharmaceutics: X · 2026 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MYD88 | “In a Complete Freund's Adjuvant-induced RA rat model, NRG-TPs/HA-MNs significantly reduced paw edema and joint swelling, preserved joint architecture on X-ray imaging, and ELISA analysis indicated significant decreases in inflammatory mediators TNF-α, IL-1β, IL-6, NF-κB, and MMP-3. qPCR analysis of the genes MYD88, TXNIP, and BCL-2 showed the therapeutic potential of this system, accompanied by decreased levels of the oxidative stress marker malondialdehyde (MDA), suggesting modulation of the mTOR signaling pathway.” | 0.98 | hgnc_dict_v1 |
| phenotype | rheumatoid arthritis | “Hyaluronic acid microneedle patch for transdermal delivery of naringin-loaded PEGylated terpesomes in a rat model of rheumatoid arthritis: Modulation TGF-β1, oxidative stress, and inflammation.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TXNIP | “In a Complete Freund's Adjuvant-induced RA rat model, NRG-TPs/HA-MNs significantly reduced paw edema and joint swelling, preserved joint architecture on X-ray imaging, and ELISA analysis indicated significant decreases in inflammatory mediators TNF-α, IL-1β, IL-6, NF-κB, and MMP-3. qPCR analysis of the genes MYD88, TXNIP, and BCL-2 showed the therapeutic potential of this system, accompanied by decreased levels of the oxidative stress marker malondialdehyde (MDA), suggesting modulation of the mTOR signaling pathway.” | 0.98 | hgnc_dict_v1 |
Deciphering the therapeutic potential of trimetazidine in rheumatoid arthritis via targeting mi-RNA128a, TLR4 signaling pathway, and adenosine-induced FADD-microvesicular shedding: In vivo and in silico study.
PMID 38919260 | PMCID PMC11196411 | DOI 10.3389/fphar.2024.1406939 · Frontiers in pharmacology · 2024 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MYD88 | “These findings were further supported by the significant activation of the TLR4/MYD88 pathway and its downstream inflammatory IkB/NFB markers.” | 0.98 | hgnc_dict_v1 |
| phenotype | rheumatoid arthritis | “Deciphering the therapeutic potential of trimetazidine in rheumatoid arthritis via targeting mi-RNA128a, TLR4 signaling pathway, and adenosine-induced FADD-microvesicular shedding: In vivo and in silico study.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TLR4 | “Deciphering the therapeutic potential of trimetazidine in rheumatoid arthritis via targeting mi-RNA128a, TLR4 signaling pathway, and adenosine-induced FADD-microvesicular shedding: In vivo and in silico study.” | 0.98 | hgnc_dict_v1 |
| gene | FADD | “Recent research has revealed the critical role of FAS-associated death domain protein (FADD) microvesicular shedding in RA pathogenesis, expanding its scope beyond apoptosis to include inflammatory and immune pathways.” | 0.98 | hgnc_dict_v1 |