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NAIP and spinal muscular atrophy are reported together in 4 articles.
Gene
NAIP
- HGNC
- HGNC:7634
6articles
6mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Spinal muscular atrophy
45articles
45mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
4 records shown · first 60Molecular analysis of the spinal muscular atrophy and neuronal apoptosis inhibitory protein genes in Saudi patients with spinal muscular atrophy.
PMID 14578966 · Saudi medical journal · 2003 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | NAIP | “Deletions or mutations in 2 genes, telomeric form of the survival motor neuron (SMN1) and the neuronal apoptosis inhibitory protein (NAIP), are known to be associated with SMA.” | 0.98 | hgnc_dict_v1 |
| phenotype | spinal muscular atrophy | “Molecular analysis of the spinal muscular atrophy and neuronal apoptosis inhibitory protein genes in Saudi patients with spinal muscular atrophy.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SMN1 | “Deletions or mutations in 2 genes, telomeric form of the survival motor neuron (SMN1) and the neuronal apoptosis inhibitory protein (NAIP), are known to be associated with SMA.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia, Riyadh | “Molecular analysis of the spinal muscular atrophy and neuronal apoptosis inhibitory protein genes in Saudi patients with spinal muscular atrophy. The prevalence of SMA cases in the Kingdom of Saudi Arabia (KSA) is much higher than the European and North American population. The aim of this study is to examine the deletions or interruptions of the SMN1 and NAIP genes in Saudi patients. METHODS: The study included 121 Saudi SMA patients [type I (60 patients); type II (26 patients); and type III (35 patients)]. The study was carried out at the King Fahad National Guard Hospital, Riyadh, KSA between 2000 and 2002. CONCLUSION: Our results demonstrate that the deletion rate (94%) of the SMN1 gene in Saudi SMA patients is similar, irrespective of types, compared with patients of other ethnic groups. We also show that the incidence of NAIP deletion is higher in the more severe SMA cases and the dual deletion of the SMN1 and NAIP genes are more common in Saudi SMA type I patients compared with patients of other ethnic groups.” | 0.95 | saudi_context_rules_v1 |
Gene deletion patterns in spinal muscular atrophy patients with different clinical phenotypes.
PMID 11287750 | DOI 10.1007/BF02256412 · Journal of biomedical science · 2001 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | NAIP | “We have assayed deletions in two candidate genes, the survival motor neuron (SMN) and neuronal apoptosis inhibitory protein (NAIP) genes, in 108 samples, of which 46 were from SMA patients, and 62 were from unaffected subjects.” | 0.98 | hgnc_dict_v1 |
| phenotype | spinal muscular atrophy | “Gene deletion patterns in spinal muscular atrophy patients with different clinical phenotypes.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “We have assayed deletions in two candidate genes, the survival motor neuron (SMN) and neuronal apoptosis inhibitory protein (NAIP) genes, in 108 samples, of which 46 were from SMA patients, and 62 were from unaffected subjects. The SMA patients included 3 from Bahrain, 9 from South Africa, 2 from India, 5 from Oman, 1 from Saudi Arabia, and 26 from Kuwait.” | 0.95 | saudi_context_rules_v1 |
Application of DNA-based tests for diagnosis of spinal muscular atrophy in Saudi Arabia.
PMID 11924116 · Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit · 1999 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | NAIP | “We examined the deletion of the survival motor neuron (SMN) and neuronal apoptosis inhibitory protein (NAIP) genes in patients with spinal muscular atrophy (SMA) using polymerase chain reaction followed by restriction site assay methods.” | 0.98 | hgnc_dict_v1 |
| phenotype | spinal muscular atrophy | “Application of DNA-based tests for diagnosis of spinal muscular atrophy in Saudi Arabia.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Application of DNA-based tests for diagnosis of spinal muscular atrophy in Saudi Arabia. The study included 16 Saudi patients (9 SMA type I and 7 SMA type II) and 6 healthy Saudi volunteers. The incidence of NAIP deletion was higher in the more severe SMA cases and the dual deletion of the SMN and NAIP genes was more common in Saudi SMA type I patients compared with patients of other ethnic groups.” | 0.95 | saudi_context_rules_v1 |
Molecular analysis of the SMN and NAIP genes in Saudi spinal muscular atrophy patients.
PMID 9667776 | DOI 10.1016/s0022-510x(98)00053-7 · Journal of the neurological sciences · 1998 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | NAIP | “Molecular analysis of the SMN and NAIP genes in Saudi spinal muscular atrophy patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | spinal muscular atrophy | “Molecular analysis of the SMN and NAIP genes in Saudi spinal muscular atrophy patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Molecular analysis of the SMN and NAIP genes in Saudi spinal muscular atrophy patients. In this study we examined the deletion of the SMN and NAIP genes in 14 Saudi families (16 patients and 38 relatives of the patients, including parents and siblings) and six healthy Saudi volunteers. All control Saudi volunteers and all but two family members of the patients had both normal SMN and NAIP genes. Our results show that the incidence of NAIP deletion is higher in the more severe SMA cases and the dual deletions of the SMN and NAIP genes are more common in Saudi SMA type-I patients compared to patients of other ethnic groups.” | 0.95 | saudi_context_rules_v1 |