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NEAT1 and breast cancer are reported together in 3 articles.
Gene
NEAT1
- HGNC
- HGNC:30815
21articles
21mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Breast cancer
1,211articles
1,211mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Deep learning-based computational approach for predicting ncRNAs-disease associations in metaplastic breast cancer diagnosis.
PMID 40329245 | PMCID PMC12053860 | DOI 10.1186/s12885-025-14113-z · BMC cancer · 2025 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | NEAT1 | “Survival analysis using TCGA data revealed prognostic significance for MALAT1, HOTAIR, and NEAT1 (associated with poor survival, HR = 1.76-2.71) and GAS5 (protective effect, HR = 0.60).” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Deep learning-based computational approach for predicting ncRNAs-disease associations in metaplastic breast cancer diagnosis.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | MALAT1 | “Survival analysis using TCGA data revealed prognostic significance for MALAT1, HOTAIR, and NEAT1 (associated with poor survival, HR = 1.76-2.71) and GAS5 (protective effect, HR = 0.60).” | 0.98 | hgnc_dict_v1 |
| gene | HOTAIR | “Survival analysis using TCGA data revealed prognostic significance for MALAT1, HOTAIR, and NEAT1 (associated with poor survival, HR = 1.76-2.71) and GAS5 (protective effect, HR = 0.60).” | 0.98 | hgnc_dict_v1 |
Exploring the role of lncrna neat1 knockdown in regulating apoptosis across multiple cancer types: A review.
PMID 37950931 | DOI 10.1016/j.prp.2023.154908 · Pathology, research and practice · 2023 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | NEAT1 | “One such lncRNA is NEAT1, which is elevated in several types of cancer and aid in cancer growth.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Additionally, we investigate the molecular mechanisms by which NEAT1 modulates the cell cycle, cellular proliferation, apoptosis, movement, and infiltration in diverse cancer types, including acute myeloid leukemia, breast cancer, cervical cancer, colorectal cancer, esophageal squamous cell carcinoma, glioma, non-small cell lung cancer, ovarian cancer, prostate cancer, and retinoblastoma.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | colorectal cancer | “Additionally, we investigate the molecular mechanisms by which NEAT1 modulates the cell cycle, cellular proliferation, apoptosis, movement, and infiltration in diverse cancer types, including acute myeloid leukemia, breast cancer, cervical cancer, colorectal cancer, esophageal squamous cell carcinoma, glioma, non-small cell lung cancer, ovarian cancer, prostate cancer, and retinoblastoma.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | lung cancer | “Additionally, we investigate the molecular mechanisms by which NEAT1 modulates the cell cycle, cellular proliferation, apoptosis, movement, and infiltration in diverse cancer types, including acute myeloid leukemia, breast cancer, cervical cancer, colorectal cancer, esophageal squamous cell carcinoma, glioma, non-small cell lung cancer, ovarian cancer, prostate cancer, and retinoblastoma.” | 0.98 | phenotype_alias_lexicon_v2 |
Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.
PMID 25417700 | PMCID PMC4430310 | DOI 10.1038/onc.2014.378 · Oncogene · 2015 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | NEAT1 | “Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Here, we show that NEAT1 long non-coding RNA (lncRNA) is a direct transcriptional target of HIF in many breast cancer cell lines and in solid tumors.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | F11R | “We show that the nuclear retention of one such transcript, F11R (also known as junctional adhesion molecule 1, JAM1), in hypoxia is dependent upon the hypoxic increase in NEAT1, thereby conferring a novel mechanism of HIF-dependent gene regulation.” | 0.98 | hgnc_dict_v1 |