Advanced search
Combine gene, variant, phenotype, region and year filters
Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
Transparent by designEvery result links extracted entities to its source sentence and publication identifier.
Knowledge-base search
About your search
NLRP3 and rheumatoid arthritis are reported together in 2 articles.
Gene
NLRP3
- HGNC
- HGNC:16400
144articles
144mentions
6variants with confirmed gene link
Most co-reported phenotypes (articles)
ulcerative colitis 17diabetes mellitus 13Alzheimer disease 7inflammatory bowel disease 6obesity 5cardiomyopathy 4renal failure 4COVID-19 3
Reported variants (articles · ClinVar status)
Phenotype
Rheumatoid arthritis
212articles
212mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Effects of Fisetin and Nicorandil on adjuvant-induced rheumatoid arthritis in rats: Emerging role of TLR4/NF-κB-induced Pyroptosis, Nrf-2/HO-1, and OPG/RANKL pathways.
PMID 39884184 | DOI 10.1016/j.cyto.2025.156876 · Cytokine · 2025 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | NLRP3 | “We assessed paw thickness, arthritis indices, serum CRP, RF, OPG, RANKL, and gene expressions of synovial TLR4, NLRP3, caspase-1, GSDMD, Nrf-2, and HO, along with synovial histopathology and NF-κB immunoreactivity.” | 0.98 | hgnc_dict_v1 |
| phenotype | rheumatoid arthritis | “Effects of Fisetin and Nicorandil on adjuvant-induced rheumatoid arthritis in rats: Emerging role of TLR4/NF-κB-induced Pyroptosis, Nrf-2/HO-1, and OPG/RANKL pathways.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TLR4 | “Effects of Fisetin and Nicorandil on adjuvant-induced rheumatoid arthritis in rats: Emerging role of TLR4/NF-κB-induced Pyroptosis, Nrf-2/HO-1, and OPG/RANKL pathways.” | 0.98 | hgnc_dict_v1 |
| gene | CRP | “We assessed paw thickness, arthritis indices, serum CRP, RF, OPG, RANKL, and gene expressions of synovial TLR4, NLRP3, caspase-1, GSDMD, Nrf-2, and HO, along with synovial histopathology and NF-κB immunoreactivity.” | 0.98 | hgnc_dict_v1 |
Deep Learning and Structure-Based Virtual Screening for Drug Discovery against NEK7: A Novel Target for the Treatment of Cancer.
PMID 35807344 | PMCID PMC9268522 | DOI 10.3390/molecules27134098 · Molecules (Basel, Switzerland) · 2022 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | NLRP3 | “NIMA-related kinase7 (NEK7) plays a multifunctional role in cell division and NLRP3 inflammasone activation.” | 0.98 | hgnc_dict_v1 |
| phenotype | rheumatoid arthritis | “A typical expression or any mutation in the genetic makeup of NEK7 leads to the development of cancer malignancies and fatal inflammatory disease, i.e., breast cancer, non-small cell lung cancer, gout, rheumatoid arthritis, and liver cirrhosis.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | NEK7 | “Deep Learning and Structure-Based Virtual Screening for Drug Discovery against NEK7: A Novel Target for the Treatment of Cancer.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “A typical expression or any mutation in the genetic makeup of NEK7 leads to the development of cancer malignancies and fatal inflammatory disease, i.e., breast cancer, non-small cell lung cancer, gout, rheumatoid arthritis, and liver cirrhosis.” | 0.98 | phenotype_alias_lexicon_v2 |