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NOTCH1 and diabetes mellitus are reported together in 1 article.
Gene
NOTCH1
- HGNC
- HGNC:7881
17articles
17mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
colorectal cancer 3breast cancer 2lymphoma 2prostate cancer 2congenital heart disease 1developmental delay 1diabetes mellitus 1
Reported variants (articles · ClinVar status)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health.
PMID 30342560 | PMCID PMC6196025 | DOI 10.1186/s13148-018-0558-0 · Clinical epigenetics · 2018 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | NOTCH1 | “Metabolic disease risk traits such as visceral fat and android-to-gynoid ratio showed association with methylation at smoking markers with functional impacts on expression, such as CYP1A1, and at tissue-shared smoking signals, such as NOTCH1.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “BACKGROUND: Tobacco smoking is a risk factor for multiple diseases, including cardiovascular disease and diabetes.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | AHRR | “RESULTS: We identified 42 smoking-methylation and 42 smoking-expression signals, where five genes (AHRR, CYP1A1, CYP1B1, CYTL1, F2RL3) were both hypo-methylated and upregulated in current smokers.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “RESULTS: We identified 42 smoking-methylation and 42 smoking-expression signals, where five genes (AHRR, CYP1A1, CYP1B1, CYTL1, F2RL3) were both hypo-methylated and upregulated in current smokers.” | 0.98 | hgnc_dict_v1 |