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NOTCH3 and Alzheimer disease are reported together in 1 article.
Gene
NOTCH3
- HGNC
- HGNC:7883
17articles
17mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
stroke 6colorectal cancer 2diabetes mellitus 2hypertension 2Alzheimer disease 1breast cancer 1intellectual disability 1neurodevelopmental disorder 1
Reported variants (articles · ClinVar status)
Phenotype
Alzheimer disease
455articles
455mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Molecular Genetics of Early- and Late-Onset Alzheimer's Disease.
PMID 33231156 | DOI 10.2174/1566523220666201123112822 · Current gene therapy · 2021 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | NOTCH3 | “Although several genes have been identified by using the technology of next-generation sequencing in EOAD families, including SORL1, TYROBP, and NOTCH3.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Molecular Genetics of Early- and Late-Onset Alzheimer's Disease.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | APP | “The genetics of EOAD is extensively understood, with three gene variants such as APP, PSEN1, and PSEN2 leading to the disease.” | 0.98 | hgnc_dict_v1 |
| gene | PSEN1 | “The genetics of EOAD is extensively understood, with three gene variants such as APP, PSEN1, and PSEN2 leading to the disease.” | 0.98 | hgnc_dict_v1 |