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NOTCH3 and diabetes mellitus are reported together in 2 articles.
Gene
NOTCH3
- HGNC
- HGNC:7883
17articles
17mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
stroke 6colorectal cancer 2diabetes mellitus 2hypertension 2Alzheimer disease 1breast cancer 1intellectual disability 1neurodevelopmental disorder 1
Reported variants (articles · ClinVar status)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Exploring the genetic frontier: Unraveling ANRIL, PAI-1, and HNF1α in stroke progression.
PMID 41379817 | PMCID PMC12698005 | DOI 10.1371/journal.pone.0332252 · PloS one · 2025 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | NOTCH3 | “Furthermore, our study identified several novel and common gene variants in stroke patients through WES, including COL4A2, PSEN2, NOTCH3, and RNF2.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “This multifaceted condition is affected by a combination of factors, including hypertension, diabetes, and genetic influences.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | COL4A2 | “Furthermore, our study identified several novel and common gene variants in stroke patients through WES, including COL4A2, PSEN2, NOTCH3, and RNF2.” | 0.98 | hgnc_dict_v1 |
| gene | PSEN2 | “Furthermore, our study identified several novel and common gene variants in stroke patients through WES, including COL4A2, PSEN2, NOTCH3, and RNF2.” | 0.98 | hgnc_dict_v1 |
Epigenetic Changes Induced by High Glucose in Human Pancreatic Beta Cells.
PMID 36815184 | PMCID PMC9940985 | DOI 10.1155/2023/9947294 · Journal of diabetes research · 2023 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | NOTCH3 | “Influence of upstream regulators such as MRTFA, AREG, and NOTCH3 was predicted based on the altered methylation of their downstream targets.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Epigenetic changes in pancreatic beta cells caused by sustained high blood glucose levels, as seen in prediabetic conditions, may contribute to the etiology of diabetes.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | MRTFA | “Influence of upstream regulators such as MRTFA, AREG, and NOTCH3 was predicted based on the altered methylation of their downstream targets.” | 0.98 | hgnc_dict_v1 |
| gene | AREG | “Influence of upstream regulators such as MRTFA, AREG, and NOTCH3 was predicted based on the altered methylation of their downstream targets.” | 0.98 | hgnc_dict_v1 |