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NOTCH3 and hypertension are reported together in 2 articles.
Gene
NOTCH3
- HGNC
- HGNC:7883
17articles
17mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
stroke 6colorectal cancer 2diabetes mellitus 2hypertension 2Alzheimer disease 1breast cancer 1intellectual disability 1neurodevelopmental disorder 1
Reported variants (articles · ClinVar status)
Phenotype
Hypertension
828articles
828mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Exploring the genetic frontier: Unraveling ANRIL, PAI-1, and HNF1α in stroke progression.
PMID 41379817 | PMCID PMC12698005 | DOI 10.1371/journal.pone.0332252 · PloS one · 2025 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | NOTCH3 | “Furthermore, our study identified several novel and common gene variants in stroke patients through WES, including COL4A2, PSEN2, NOTCH3, and RNF2.” | 0.98 | hgnc_dict_v1 |
| phenotype | hypertension | “This multifaceted condition is affected by a combination of factors, including hypertension, diabetes, and genetic influences.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | COL4A2 | “Furthermore, our study identified several novel and common gene variants in stroke patients through WES, including COL4A2, PSEN2, NOTCH3, and RNF2.” | 0.98 | hgnc_dict_v1 |
| gene | PSEN2 | “Furthermore, our study identified several novel and common gene variants in stroke patients through WES, including COL4A2, PSEN2, NOTCH3, and RNF2.” | 0.98 | hgnc_dict_v1 |
miR-150-PTPMT1-cardiolipin signaling in pulmonary arterial hypertension.
PMID 33335799 | PMCID PMC7733016 | DOI 10.1016/j.omtn.2020.10.042 · Molecular therapy. Nucleic acids · 2021 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | NOTCH3 | “Beneficial effects of miR-150 in vitro and in vivo were linked with PTPMT1-dependent biosynthesis of mitochondrial phospholipid cardiolipin and reduced expression of pro-apoptotic, pro-inflammatory, and pro-fibrotic genes, including c-MYB, NOTCH3, transforming growth factor β (TGF-β), and Col1a1.” | 0.98 | hgnc_dict_v1 |
| phenotype | hypertension | “miR-150-PTPMT1-cardiolipin signaling in pulmonary arterial hypertension.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PTPMT1 | “Endothelium-targeted miR-150 delivery prevented the disease in Sugen/hypoxia mice, while endothelial knockdown of miR-150 had adverse effects. miR-150 target genes revealed significant associations with PAH pathways, including proliferation, inflammation, and phospholipid signaling, with PTEN-like mitochondrial phosphatase (PTPMT1) most markedly altered.” | 0.98 | hgnc_dict_v1 |