Advanced search
Combine gene, variant, phenotype, region and year filters
Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
Transparent by designEvery result links extracted entities to its source sentence and publication identifier.
Knowledge-base search
About your search
PCSK9 and obesity are reported together in 2 articles.
Gene
PCSK9
- HGNC
- HGNC:20001
66articles
66mentions
9variants with confirmed gene link
Most co-reported phenotypes (articles)
familial hypercholesterolemia 25dyslipidemia 10diabetes mellitus 7myocardial infarction 7coronary artery disease 4stroke 3hypertension 2obesity 2
Reported variants (articles · ClinVar status)
Phenotype
Obesity
- HPO
- HP:0001513
856articles
856mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60The omics revolution in obesity: from molecularsignatures to clinical solutions.
PMID 41133487 | DOI 10.1039/d5mo00074b · Molecular omics · 2025 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PCSK9 | “Proteomic markers like proprotein convertase subtilisin/kexin type 9 (PCSK9) and retinol binding protein 4 (RBP4) are being evaluated for cardiovascular risk stratification independent of body mass index (BMI).” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “The omics revolution in obesity: from molecularsignatures to clinical solutions.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CPT1A | “Epigenomic profiling, particularly deoxy ribose nucleic acid (DNA) methylation signatures such as those at carnitine palmitoyl transferase 1A (CPT1A) and hypoxia inducible factor 3 subunit alpha (HIF3A), has uncovered modifiable pathways linked to adiposity and metabolic dysfunction.” | 0.98 | hgnc_dict_v1 |
| gene | HIF3A | “Epigenomic profiling, particularly deoxy ribose nucleic acid (DNA) methylation signatures such as those at carnitine palmitoyl transferase 1A (CPT1A) and hypoxia inducible factor 3 subunit alpha (HIF3A), has uncovered modifiable pathways linked to adiposity and metabolic dysfunction.” | 0.98 | hgnc_dict_v1 |
The Spectrum of Familial Hypercholesterolemia (FH) in Saudi Arabia: Prime Time for Patient FH Registry.
PMID 28868092 | PMCID PMC5564019 | DOI 10.2174/1874192401711010066 · The open cardiovascular medicine journal · 2017 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PCSK9 | “The underlying molecular basis of FH is the presence of mutations in one or more genes in the low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB) or proprotein convertase subtilisin/kexin 9 (PCSK9).” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Furthermore, the high prevalence of obesity and diabetes mellitus in Saudi Arabia increases the vascular disease burden in FH cases by adding additional CVD risk factors.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | LDLR | “The underlying molecular basis of FH is the presence of mutations in one or more genes in the low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB) or proprotein convertase subtilisin/kexin 9 (PCSK9).” | 0.98 | hgnc_dict_v1 |
| gene | APOB | “The underlying molecular basis of FH is the presence of mutations in one or more genes in the low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB) or proprotein convertase subtilisin/kexin 9 (PCSK9).” | 0.98 | hgnc_dict_v1 |