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PIK3CA and hepatocellular carcinoma are reported together in 2 articles.
Gene
PIK3CA
- HGNC
- HGNC:8975
77articles
77mentions
4variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 20colorectal cancer 16thyroid cancer 8lung cancer 4diabetes mellitus 3hepatocellular carcinoma 2ovarian cancer 2asthma 1
Reported variants (articles · ClinVar status)
Phenotype
Hepatocellular carcinoma
417articles
417mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Genomic landscape in Saudi patients with hepatocellular carcinoma using whole-genome sequencing: a pilot study.
PMID 41821813 | PMCID PMC12952451 | DOI 10.3389/fgstr.2023.1205415 · Frontiers in gastroenterology (Lausanne, Switzerland) · 2023 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PIK3CA | “The study also revealed the presence of specific somatic aberrations, including TP53, PIK3CA, APOB, CTNNB1, DPYD, LRP1B, MYC, and NFE2L2, which were identified in two patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Genomic landscape in Saudi patients with hepatocellular carcinoma using whole-genome sequencing: a pilot study.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TP53 | “The study also revealed the presence of specific somatic aberrations, including TP53, PIK3CA, APOB, CTNNB1, DPYD, LRP1B, MYC, and NFE2L2, which were identified in two patients.” | 0.98 | hgnc_dict_v1 |
| gene | APOB | “The study also revealed the presence of specific somatic aberrations, including TP53, PIK3CA, APOB, CTNNB1, DPYD, LRP1B, MYC, and NFE2L2, which were identified in two patients.” | 0.98 | hgnc_dict_v1 |
Mutations in TP53 and PIK3CA genes in hepatocellular carcinoma patients are associated with chronic Schistosomiasis.
PMID 35197752 | PMCID PMC8847977 | DOI 10.1016/j.sjbs.2021.10.022 · Saudi journal of biological sciences · 2022 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PIK3CA | “Mutations in TP53 and PIK3CA genes in hepatocellular carcinoma patients are associated with chronic Schistosomiasis.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Mutations in TP53 and PIK3CA genes in hepatocellular carcinoma patients are associated with chronic Schistosomiasis.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TP53 | “Mutations in TP53 and PIK3CA genes in hepatocellular carcinoma patients are associated with chronic Schistosomiasis.” | 0.98 | hgnc_dict_v1 |