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PIK3CA and ovarian cancer are reported together in 2 articles.
Gene
PIK3CA
- HGNC
- HGNC:8975
77articles
77mentions
4variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 20colorectal cancer 16thyroid cancer 8lung cancer 4diabetes mellitus 3hepatocellular carcinoma 2ovarian cancer 2asthma 1
Reported variants (articles · ClinVar status)
Phenotype
Ovarian cancer
173articles
173mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Screening for PIK3CA mutations among Saudi women with ovarian cancer.
PMID 33475035 | DOI 10.1080/01443615.2020.1839871 · Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2021 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PIK3CA | “Screening for PIK3CA mutations among Saudi women with ovarian cancer.” | 0.98 | hgnc_dict_v1 |
| phenotype | ovarian cancer | “Screening for PIK3CA mutations among Saudi women with ovarian cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Screening for PIK3CA mutations among Saudi women with ovarian cancer. The study aimed to screen for PIK3CA gene mutations among Saudi women with Ovarian Cancer. The study included 298 Saudi women with epithelial ovarian cancers (EOC). The Mutated PIK3CA gene was significantly involved in the pathogenesis of EOC among Saudi women.” | 0.95 | saudi_context_rules_v1 |
PIK3CA alterations in Middle Eastern ovarian cancers.
PMID 19638206 | PMCID PMC2724395 | DOI 10.1186/1476-4598-8-51 · Molecular cancer · 2009 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PIK3CA | “PIK3CA alterations in Middle Eastern ovarian cancers.” | 0.98 | hgnc_dict_v1 |
| phenotype | ovarian cancer | “However the role of this oncogenic signaling pathway has not been explored in the Middle Eastern epithelial ovarian cancer (EOC).” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PTEN | “Therefore, we investigated PI3K/AKT genetic alterations such as PIK3CA amplification, PIK3CA mutation, PTEN protein loss and their relationships with various clinicopathological characteristics in 156 EOCs.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “PIK3CA amplification was seen in 54 of 152 (35.5%) EOC cases analyzed; PIK3CA gene mutations in 6/153 EOC (3.9%); KRAS mutations in 3/154 EOC (1.9%), BRAF mutations in 3/156 EOC (1.9%), p53 mutation in 50/154 EOC (32.5%), and loss of PTEN protein expression in 33/144 EOC (22.9%). p110 alpha overexpression was associated with increased phosphorylation of AKT-Ser 473 and with the proliferation marker Ki-67.” | 0.98 | hgnc_dict_v1 |