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PINK1 and breast cancer are reported together in 1 article.
Gene
PINK1
- HGNC
- HGNC:14581
16articles
16mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
Parkinson disease 10Alzheimer disease 1amyotrophic lateral sclerosis 1breast cancer 1cardiomyopathy 1diabetes mellitus 1multiple sclerosis 1stroke 1
Reported variants (articles · ClinVar status)
Phenotype
Breast cancer
1,211articles
1,211mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Dose-dependent neurotoxic effects of anastrozole via disrupting NLRP3 inflammasome and α-synuclein pathways.
PMID 42139902 | DOI 10.1016/j.tice.2026.103590 · Tissue & cell · 2026 · 13 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PINK1 | “It was found that ANZ intoxication promoted the gene expression of NLRP3, PYCARD, CASP1, IL1-β, IL18, TXNIP, SNCA, and LRRK2 while suppressing the expression of PARK2, PINK1, PARK7 and UCHL1 in dose dependent manner.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Anastrozole (ANZ) is a commonly used aromatase inhibitor in the treatment of hormone-dependent breast cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | NLRP3 | “Dose-dependent neurotoxic effects of anastrozole via disrupting NLRP3 inflammasome and α-synuclein pathways.” | 0.98 | hgnc_dict_v1 |
| gene | PYCARD | “It was found that ANZ intoxication promoted the gene expression of NLRP3, PYCARD, CASP1, IL1-β, IL18, TXNIP, SNCA, and LRRK2 while suppressing the expression of PARK2, PINK1, PARK7 and UCHL1 in dose dependent manner.” | 0.98 | hgnc_dict_v1 |