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PLEC and atopic dermatitis are reported together in 1 article.
Gene
PLEC
- HGNC
- HGNC:9069
5articles
5mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Atopic dermatitis
132articles
132mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60The expression of pruritus-associated genes in seven skin diseases: Evidence from microarray.
PMID 41081460 | DOI 10.1111/jdv.70109 · Journal of the European Academy of Dermatology and Venereology : JEADV · 2026 · 18 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PLEC | “We found the top differentially upregulated pruritus-associated genes were CLEC7A, IL7R and TNFRSF1B in acne; HLA-DRA, IL2RG and POU2AF1 in alopecia areata; IL2RG, PLEC and CTLA4 in atopic dermatitis; CLEC7A, IL7R and LIPA in cutaneous lupus erythematosus; HLA-DRA, ABCA12 and IL7R in lichen planus; CLEC7A, TGM1 and SDR9C7 in psoriasis and IL7R, HLA-DRB1/HLA-DRB3/HLA-DRB4/HLA-DRB5/LOC105369230 and POU2AF1 in rosacea.” | 0.98 | hgnc_dict_v1 |
| phenotype | atopic dermatitis | “BACKGROUND: Pruritus may accompany different skin diseases including atopic dermatitis, lichen planus, psoriasis, cutaneous lupus erythematosus, acne, alopecia areata and rosacea.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CLEC7A | “We found the top differentially upregulated pruritus-associated genes were CLEC7A, IL7R and TNFRSF1B in acne; HLA-DRA, IL2RG and POU2AF1 in alopecia areata; IL2RG, PLEC and CTLA4 in atopic dermatitis; CLEC7A, IL7R and LIPA in cutaneous lupus erythematosus; HLA-DRA, ABCA12 and IL7R in lichen planus; CLEC7A, TGM1 and SDR9C7 in psoriasis and IL7R, HLA-DRB1/HLA-DRB3/HLA-DRB4/HLA-DRB5/LOC105369230 and POU2AF1 in rosacea.” | 0.98 | hgnc_dict_v1 |
| gene | IL7R | “We found the top differentially upregulated pruritus-associated genes were CLEC7A, IL7R and TNFRSF1B in acne; HLA-DRA, IL2RG and POU2AF1 in alopecia areata; IL2RG, PLEC and CTLA4 in atopic dermatitis; CLEC7A, IL7R and LIPA in cutaneous lupus erythematosus; HLA-DRA, ABCA12 and IL7R in lichen planus; CLEC7A, TGM1 and SDR9C7 in psoriasis and IL7R, HLA-DRB1/HLA-DRB3/HLA-DRB4/HLA-DRB5/LOC105369230 and POU2AF1 in rosacea.” | 0.98 | hgnc_dict_v1 |