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PLS3 and spinal muscular atrophy are reported together in 2 articles.
Gene
PLS3
- HGNC
- HGNC:9091
3articles
3mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Spinal muscular atrophy
45articles
45mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Evaluation of the role of an antioxidant gene in NSC-34 motor neuron-like cells as a model of a motor neuron disease.
PMID 30106460 | DOI 10.5603/FM.a2018.0072 · Folia morphologica · 2019 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PLS3 | “As plastin 3 (PLS3) has been demonstrated as a modifier of spinal muscular atrophy, the aim of the current study was to evaluate the neuroprotective effect of PLS3 in NSC-34 cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | spinal muscular atrophy | “BACKGROUND: Spinal muscular atrophy is a rare genetic disease, which primarily affects motor neurons and predominantly occurs in children.” | 0.98 | phenotype_alias_lexicon_v2 |
Plastin 3 Promotes Motor Neuron Axonal Growth and Extends Survival in a Mouse Model of Spinal Muscular Atrophy.
PMID 29552580 | PMCID PMC5852384 | DOI 10.1016/j.omtm.2018.01.007 · Molecular therapy. Methods & clinical development · 2018 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PLS3 | “The actin-binding protein plastin 3 (PLS3) has been reported as a modifier for SMA, making it a potential therapeutic target.” | 0.98 | hgnc_dict_v1 |
| phenotype | spinal muscular atrophy | “Plastin 3 Promotes Motor Neuron Axonal Growth and Extends Survival in a Mouse Model of Spinal Muscular Atrophy.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SMN1 | “SMA is caused by mutations in the survival motor neuron gene (SMN1), leading to reduced levels of SMN protein in the CNS.” | 0.98 | hgnc_dict_v1 |