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PRKCD and systemic lupus erythematosus are reported together in 2 articles.
Gene
PRKCD
- HGNC
- HGNC:9399
6articles
6mentions
5variants with confirmed gene link
Most co-reported phenotypes (articles)
Reported variants (articles · ClinVar status)
Phenotype
Systemic lupus erythematosus
191articles
191mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Clinical Response to Baricitinib in Monogenic Lupus: Real-World Evidence from a Case Series of Seven Patients.
PMID 42100058 | PMCID PMC13145278 | DOI 10.31138/mjr.160625.dsh · Mediterranean journal of rheumatology · 2026 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PRKCD | “RESULTS: Seven patients with mutations in C1q, DNase1L3, PRKCD, and NRAS were included.” | 0.98 | hgnc_dict_v1 |
| phenotype | systemic lupus erythematosus | “Clinical Response to Baricitinib in Monogenic Lupus: Real-World Evidence from a Case Series of Seven Patients.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | NRAS | “RESULTS: Seven patients with mutations in C1q, DNase1L3, PRKCD, and NRAS were included.” | 0.98 | hgnc_dict_v1 |
Protein Kinase Cδ deficiency in Arab children: A link to fatal monogenic lupus and BCGitis susceptibility.
PMID 41170730 | DOI 10.1177/09612033251390628 · Lupus · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PRKCD | “Variants in Protein Kinase Cδ (PRKCD) are known contributors, though remain underreported.ObjectiveTo describe the phenotypic, genetic, and outcome profiles of Arab children with monogenic lupus and PRKCD deficiency.MethodsWe retrospectively reviewed medical records of children with PRKCD deficiency lupus at two institutions in Saudi Arabia and Oman.” | 0.98 | hgnc_dict_v1 |
| phenotype | systemic lupus erythematosus | “Protein Kinase Cδ deficiency in Arab children: A link to fatal monogenic lupus and BCGitis susceptibility.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Variants in Protein Kinase Cδ (PRKCD) are known contributors, though remain underreported.ObjectiveTo describe the phenotypic, genetic, and outcome profiles of Arab children with monogenic lupus and PRKCD deficiency.MethodsWe retrospectively reviewed medical records of children with PRKCD deficiency lupus at two institutions in Saudi Arabia and Oman. Demographic, clinical, genetic, and follow-up outcome data were collected and analyzed.ResultsSeven children (four females) from three unrelated consanguineous Arab families were identified, with four having confirmed PRKCD variants.” | 0.95 | saudi_context_rules_v1 |