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PRKN and neurodevelopmental disorder are reported together in 1 article.
Gene
PRKN
- HGNC
- HGNC:8607
6articles
6mentions
3variants with confirmed gene link
Most co-reported phenotypes (articles)
Reported variants (articles · ClinVar status)
Phenotype
Neurodevelopmental disorder
- HPO
- HP:0012759
450articles
450mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Investigating the link between microplastic exposure (benzyl butyl phthalate) and neurodegenerative diseases using high-performance computational toxicology.
PMID 39830890 | PMCID PMC11741681 | DOI 10.1093/toxres/tfae211 · Toxicology research · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PRKN | “The findings indicate that BBP has a strong potential to interact with Parkin (PRKN) and Pyruvate dehydrogenase lipoamide kinase isozyme 1 (PDK1), with binding scores of -5.35 kcal/mol, -5.56 kcal/mol, respectively.” | 0.98 | hgnc_dict_v1 |
| phenotype | neurodevelopmental disorder | “AIM: Research suggests that BBP, like other phthalates, may have neurotoxic effects, potentially contributing to neurodevelopmental disorders, though its specific toxic targets are not yet clear.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | PDK1 | “The findings indicate that BBP has a strong potential to interact with Parkin (PRKN) and Pyruvate dehydrogenase lipoamide kinase isozyme 1 (PDK1), with binding scores of -5.35 kcal/mol, -5.56 kcal/mol, respectively.” | 0.98 | hgnc_dict_v1 |