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PTEN and Alzheimer disease are reported together in 4 articles.
Gene
PTEN
- HGNC
- HGNC:9588
132articles
132mentions
3variants with confirmed gene link
Most co-reported phenotypes (articles)
colorectal cancer 17breast cancer 14prostate cancer 13thyroid cancer 7diabetes mellitus 6lung cancer 5Alzheimer disease 4hepatocellular carcinoma 3
Reported variants (articles · ClinVar status)
Phenotype
Alzheimer disease
455articles
455mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
4 records shown · first 60Targeting of PP2 A/GSK3β/PTEN Axis in Alzheimer Disease: The Mooting Evidence, Divine, and Devil.
PMID 40251348 | PMCID PMC12008108 | DOI 10.1007/s10571-025-01554-0 · Cellular and molecular neurobiology · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PTEN | “Targeting of PP2 A/GSK3β/PTEN Axis in Alzheimer Disease: The Mooting Evidence, Divine, and Devil.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Targeting of PP2 A/GSK3β/PTEN Axis in Alzheimer Disease: The Mooting Evidence, Divine, and Devil.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | intellectual disability | “PP2A which involved in the dephosphorylation of tau protein is deregulated in AD, and correlated with cognitive impairment.” | 0.93 | phenotype_alias_lexicon_v2 |
MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment.
PMID 37487248 | DOI 10.1016/j.compbiolchem.2023.107925 · Computational biology and chemistry · 2023 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PTEN | “MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | BRCA1 | “MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment.” | 0.98 | phenotype_alias_lexicon_v2 |
Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer's disease.
PMID 35024240 | PMCID PMC8714918 | DOI 10.1016/j.omtn.2021.11.019 · Molecular therapy. Nucleic acids · 2022 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PTEN | “Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer's disease.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer's disease.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CDK5 | “Upregulation of miR-148a-3p was found to protect neuronal cells against Aβ-associated tau hyperphosphorylation by directly targeting p35/CDK5 and PTEN/p38 mitogen-activated protein kinase (MAPK) pathways.” | 0.98 | hgnc_dict_v1 |
Symptomatic, Genetic, and Mechanistic Overlaps between Autism and Alzheimer's Disease.
PMID 34827633 | PMCID PMC8615882 | DOI 10.3390/biom11111635 · Biomolecules · 2021 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PTEN | “A number of genes and proteins linked with both disorders have been tabulated, including MECP2, ADNP, SCN2A, NLGN, SHANK, PTEN, RELN, and FMR1.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Symptomatic, Genetic, and Mechanistic Overlaps between Autism and Alzheimer's Disease.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | MECP2 | “A number of genes and proteins linked with both disorders have been tabulated, including MECP2, ADNP, SCN2A, NLGN, SHANK, PTEN, RELN, and FMR1.” | 0.98 | hgnc_dict_v1 |
| gene | ADNP | “A number of genes and proteins linked with both disorders have been tabulated, including MECP2, ADNP, SCN2A, NLGN, SHANK, PTEN, RELN, and FMR1.” | 0.98 | hgnc_dict_v1 |