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PTEN and gastric cancer are reported together in 2 articles.
Gene
PTEN
- HGNC
- HGNC:9588
132articles
132mentions
3variants with confirmed gene link
Most co-reported phenotypes (articles)
colorectal cancer 17breast cancer 14prostate cancer 13thyroid cancer 7diabetes mellitus 6lung cancer 5Alzheimer disease 4hepatocellular carcinoma 3
Reported variants (articles · ClinVar status)
Phenotype
Gastric cancer
106articles
106mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Dual primary gastric and colorectal cancer: The known hereditary causes and underlying mechanisms.
PMID 38994141 | PMCID PMC11236243 | DOI 10.4251/wjgo.v16.i6.2264 · World journal of gastrointestinal oncology · 2024 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PTEN | “These include hereditary diffuse GC, familial adenomatous polyposis, hereditary nonpolyposis colon cancer, Lynch syndrome, and three major hamartomatous polyposis syndromes associated with CRC and GC, namely Peutz-Jeghers syndrome, juvenile polyposis syndrome, and PTEN hamartoma syndrome.” | 0.98 | hgnc_dict_v1 |
| phenotype | gastric cancer | “The authors concluded the necessity for regular surveillance for metachronous cancer during postoperative follow-up and reported the prognosis is influenced by the gastric cancer (GC) stage rather than the CRC stage.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | colorectal cancer | “Dual primary gastric and colorectal cancer: The known hereditary causes and underlying mechanisms.” | 0.98 | phenotype_alias_lexicon_v2 |
A state-of-art of underlying molecular mechanisms and pharmacological interventions/nanotherapeutics for cisplatin resistance in gastric cancer.
PMID 37659203 | DOI 10.1016/j.biopha.2023.115337 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PTEN | “Dysregulation of molecular pathways such as PTEN, PI3K/Akt, Nrf2 and others result in changes in CP response of GC cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | gastric cancer | “A state-of-art of underlying molecular mechanisms and pharmacological interventions/nanotherapeutics for cisplatin resistance in gastric cancer.” | 0.98 | phenotype_alias_lexicon_v2 |