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RAD51 and breast cancer are reported together in 11 articles.
Gene
RAD51
- HGNC
- HGNC:9817
24articles
24mentions
3variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 11COVID-19 1SARS 1hepatocellular carcinoma 1inflammatory bowel disease 1lung cancer 1neurodevelopmental disorder 1ovarian cancer 1
Reported variants (articles · ClinVar status)
Phenotype
Breast cancer
1,211articles
1,211mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
11 records shown · first 60The influence of RAD51 (rs1801320) on breast cancer risk: an updated meta-analysis.
PMID 40063134 | PMCID PMC11893934 | DOI 10.1007/s12672-025-02012-5 · Discover oncology · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | RAD51 | “The influence of RAD51 (rs1801320) on breast cancer risk: an updated meta-analysis.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “The influence of RAD51 (rs1801320) on breast cancer risk: an updated meta-analysis.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs1801320 | “The influence of RAD51 (rs1801320) on breast cancer risk: an updated meta-analysis.” | 0.90 | hgvs_regex_v1 |
Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers.
PMID 34782604 | PMCID PMC8593132 | DOI 10.1038/s41523-021-00350-5 · NPJ breast cancer · 2021 · 18 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | RAD51 | “We have protein expression profiled for MRN and a panel of DNA repair factors involved in double-strand break repair (BRCA1, BRCA2, ATM, CHK2, ATR, Chk1, pChk1, RAD51, γH2AX, RPA1, RPA2, DNA-PKcs), RECQ DNA helicases (BLM, WRN, RECQ1, RECQL4, RECQ5), nucleotide excision repair (ERCC1) and base excision repair (SMUG1, APE1, FEN1, PARP1, XRCC1, Pol β) in 1650 clinical breast cancers.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Although germline mutations in MRN may increase breast cancer susceptibility, such mutations are extremely rare.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BRCA1 | “We have protein expression profiled for MRN and a panel of DNA repair factors involved in double-strand break repair (BRCA1, BRCA2, ATM, CHK2, ATR, Chk1, pChk1, RAD51, γH2AX, RPA1, RPA2, DNA-PKcs), RECQ DNA helicases (BLM, WRN, RECQ1, RECQL4, RECQ5), nucleotide excision repair (ERCC1) and base excision repair (SMUG1, APE1, FEN1, PARP1, XRCC1, Pol β) in 1650 clinical breast cancers.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA2 | “We have protein expression profiled for MRN and a panel of DNA repair factors involved in double-strand break repair (BRCA1, BRCA2, ATM, CHK2, ATR, Chk1, pChk1, RAD51, γH2AX, RPA1, RPA2, DNA-PKcs), RECQ DNA helicases (BLM, WRN, RECQ1, RECQL4, RECQ5), nucleotide excision repair (ERCC1) and base excision repair (SMUG1, APE1, FEN1, PARP1, XRCC1, Pol β) in 1650 clinical breast cancers.” | 0.98 | hgnc_dict_v1 |
Polymorphic Variants in 5'-UTR Regions of the RAD51 Gene are Associated With RAD51 Expression and Triple-Negative Breast Cancer (TNBC): A Case-Control Study.
PMID 33417321 | DOI 10.1097/PAI.0000000000000900 · Applied immunohistochemistry & molecular morphology : AIMM · 2021 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | RAD51 | “Polymorphic Variants in 5'-UTR Regions of the RAD51 Gene are Associated With RAD51 Expression and Triple-Negative Breast Cancer (TNBC): A Case-Control Study.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Polymorphic Variants in 5'-UTR Regions of the RAD51 Gene are Associated With RAD51 Expression and Triple-Negative Breast Cancer (TNBC): A Case-Control Study.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | G135C | “Considering the numerous reports on the role of the 5'-UTR-RAD51 polymorphism in breast cancer, this study aimed to investigate the utility of RAD51 gene expression and its variants G135C and G172T as a possible foretelling factor of breast cancer development.” | 0.82 | literature_variant_regex_v2 |
| variant | G172T | “Considering the numerous reports on the role of the 5'-UTR-RAD51 polymorphism in breast cancer, this study aimed to investigate the utility of RAD51 gene expression and its variants G135C and G172T as a possible foretelling factor of breast cancer development.” | 0.82 | literature_variant_regex_v2 |
Exploring the Molecular Mechanism of the Drug-Treated Breast Cancer Based on Gene Expression Microarray.
PMID 31311202 | PMCID PMC6681318 | DOI 10.3390/biom9070282 · Biomolecules · 2019 · 19 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | RAD51 | “DEGs (MCM2, TCF4, OLR1, HSPA5, MAP1LC3B, SQSTM1, NEU1, HIST1H1B, RAD51, RFC3, MCM10, ISG15, TNFRSF10B, GBP2, IGFBP5, SOD2, DHF and MT1H) , which were significantly up- and down-regulated in estradiol and tamoxifen-treated BRCA samples, were selected as hub genes according to the results of protein-protein interaction (PPI) network, module analysis, target genes-miRNA interaction network and target genes-TF interaction network analysis.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Exploring the Molecular Mechanism of the Drug-Treated Breast Cancer Based on Gene Expression Microarray. : Breast cancer (BRCA) remains the leading cause of cancer morbidity and mortality worldwide.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TF | “The pathway and gene ontology (GO) enrichment analysis, construction of protein-protein interaction (PPI) network, module analysis, construction of target genes-miRNA interaction network and target genes-transcription factor (TF) interaction network were performed using bioinformatics tools.” | 0.98 | hgnc_dict_v1 |
| gene | SPEN | “A total of 856 genes (421 up-regulated genes and 435 down-regulated genes) were identified in T47D (overexpressing Split Ends (SPEN) + estradiol) samples compared to T47D (overexpressing Split Ends (SPEN) + tamoxifen) samples.” | 0.98 | hgnc_dict_v1 |
Comprehensive molecular biomarker identification in breast cancer brain metastases.
PMID 29287594 | PMCID PMC5747948 | DOI 10.1186/s12967-017-1370-x · Journal of translational medicine · 2017 · 45 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | RAD51 | “RESULTS: The top 370 probe sets that were differentially expressed between BCBM and both BC and prBT were in the majority comparably overexpressed in BCBM and included, e.g. the coding genes BCL3, BNIP3, BNIP3P1, BRIP1, CASP14, CDC25A, DMBT1, IDH2, E2F1, MYCN, RAD51, RAD54L, and VDR.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Comprehensive molecular biomarker identification in breast cancer brain metastases.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BCL3 | “RESULTS: The top 370 probe sets that were differentially expressed between BCBM and both BC and prBT were in the majority comparably overexpressed in BCBM and included, e.g. the coding genes BCL3, BNIP3, BNIP3P1, BRIP1, CASP14, CDC25A, DMBT1, IDH2, E2F1, MYCN, RAD51, RAD54L, and VDR.” | 0.98 | hgnc_dict_v1 |
| gene | BNIP3 | “RESULTS: The top 370 probe sets that were differentially expressed between BCBM and both BC and prBT were in the majority comparably overexpressed in BCBM and included, e.g. the coding genes BCL3, BNIP3, BNIP3P1, BRIP1, CASP14, CDC25A, DMBT1, IDH2, E2F1, MYCN, RAD51, RAD54L, and VDR.” | 0.98 | hgnc_dict_v1 |
Polymorphisms and mutations in GSTP1, RAD51, XRCC1 and XRCC3 genes in breast cancer patients.
PMID 28315507 | DOI 10.5301/ijbm.5000258 · The International journal of biological markers · 2017 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | RAD51 | “Polymorphisms and mutations in GSTP1, RAD51, XRCC1 and XRCC3 genes in breast cancer patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Polymorphisms and mutations in GSTP1, RAD51, XRCC1 and XRCC3 genes in breast cancer patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | GSTP1 | “Polymorphisms and mutations in GSTP1, RAD51, XRCC1 and XRCC3 genes in breast cancer patients.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Polymorphisms and mutations in GSTP1, RAD51, XRCC1 and XRCC3 genes in breast cancer patients.” | 0.98 | hgnc_dict_v1 |
Polymorphisms in RAD51 and their relation with breast cancer in Saudi females.
PMID 26834486 | PMCID PMC4716748 | DOI 10.2147/OTT.S93343 · OncoTargets and therapy · 2016 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | RAD51 | “Polymorphisms in RAD51 and their relation with breast cancer in Saudi females.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Polymorphisms in RAD51 and their relation with breast cancer in Saudi females.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Polymorphisms in RAD51 and their relation with breast cancer in Saudi females. The present study aimed at investigating the relationship between rs1801320 (G>C), rs1801321 (G>T), and rs2619681 (C>T) RAD51 gene polymorphisms and the risk of breast cancer development in Saudi females. In the Saudi females, rs1801320 did not show an association with risk of breast cancer. Taken together, the results suggest that RAD51 rs1801321 polymorphism may be involved in the etiology of breast cancer in the Saudi females; however, further studies are necessary to confirm this relation.” | 0.95 | saudi_context_rules_v1 |
| variant | rs1801320 | “The present study aimed at investigating the relationship between rs1801320 (G>C), rs1801321 (G>T), and rs2619681 (C>T) RAD51 gene polymorphisms and the risk of breast cancer development in Saudi females.” | 0.90 | hgvs_regex_v1 |
Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility.
PMID 26650628 | DOI 10.1007/s10528-015-9703-z · Biochemical genetics · 2016 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | RAD51 | “Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | T172T | “Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility.” | 0.82 | literature_variant_regex_v2 |
| variant | G135C | “Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility.” | 0.82 | literature_variant_regex_v2 |
Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response protein.
PMID 27464795 | DOI 10.1007/s10549-016-3915-8 · Breast cancer research and treatment · 2016 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | RAD51 | “Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response protein.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response protein.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BRCA1 | “A subset of cases of BC from patients with known BRCA1 germline mutations was included as a control group.” | 0.98 | hgnc_dict_v1 |
| gene | RAD51C | “Cytoplasmic expression (RAD51C(+)) and lack of nuclear expression (RAD51 N(-)) were associated with features of aggressive behaviour, including larger tumour size, high grade, lymph nodal metastasis, basal-like, and triple-negative phenotypes, together with aberrant expression of key DDR biomarkers including BRCA1.” | 0.98 | hgnc_dict_v1 |
Checkpoint kinase1 (CHK1) is an important biomarker in breast cancer having a role in chemotherapy response.
PMID 25688741 | PMCID PMC4453942 | DOI 10.1038/bjc.2014.576 · British journal of cancer · 2015 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | RAD51 | “On the other hand, cytoplasmic expression was associated with features of poor prognosis such as higher grade, triple-negative phenotype and expression of KI67, p53, AKT and PI3K. pCHK1 expression showed an association with DNA damage response (ATM, RAD51, BRCA1, KU70/KU80, DNA-PKCα and BARD1) and sumoylation (UBC9 and PIASγ) biomarkers.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Checkpoint kinase1 (CHK1) is an important biomarker in breast cancer having a role in chemotherapy response.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ATM | “On the other hand, cytoplasmic expression was associated with features of poor prognosis such as higher grade, triple-negative phenotype and expression of KI67, p53, AKT and PI3K. pCHK1 expression showed an association with DNA damage response (ATM, RAD51, BRCA1, KU70/KU80, DNA-PKCα and BARD1) and sumoylation (UBC9 and PIASγ) biomarkers.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “On the other hand, cytoplasmic expression was associated with features of poor prognosis such as higher grade, triple-negative phenotype and expression of KI67, p53, AKT and PI3K. pCHK1 expression showed an association with DNA damage response (ATM, RAD51, BRCA1, KU70/KU80, DNA-PKCα and BARD1) and sumoylation (UBC9 and PIASγ) biomarkers.” | 0.98 | hgnc_dict_v1 |
KPNA2 is a nuclear export protein that contributes to aberrant localisation of key proteins and poor prognosis of breast cancer.
PMID 25989275 | PMCID PMC4580386 | DOI 10.1038/bjc.2015.165 · British journal of cancer · 2015 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | RAD51 | “RESULTS: KPNA2 expression was associated with the subcellular localisation of key DDR proteins that showed cytoplasmic expression including BRCA1, RAD51, SMC6L1, γH2AX, BARD1, UBC9, PIAS1 and CHK1.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “KPNA2 is a nuclear export protein that contributes to aberrant localisation of key proteins and poor prognosis of breast cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | KPNA2 | “KPNA2 is a nuclear export protein that contributes to aberrant localisation of key proteins and poor prognosis of breast cancer.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “RESULTS: KPNA2 expression was associated with the subcellular localisation of key DDR proteins that showed cytoplasmic expression including BRCA1, RAD51, SMC6L1, γH2AX, BARD1, UBC9, PIAS1 and CHK1.” | 0.98 | hgnc_dict_v1 |