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RUNX1 and diabetes mellitus are reported together in 1 article.
Gene
RUNX1
- HGNC
- HGNC:10471
25articles
25mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
leukemia 14Down syndrome 2breast cancer 1diabetes mellitus 1hepatocellular carcinoma 1myocardial infarction 1rheumatoid arthritis 1
Reported variants (articles · ClinVar status)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Dysregulation of macrophage development and phenotype in diabetic human macrophages can be rescued by Hoxa3 protein transduction.
PMID 31626638 | PMCID PMC6799902 | DOI 10.1371/journal.pone.0223980 · PloS one · 2019 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | RUNX1 | “In addition, diabetic-derived macrophages show maturation defects associated with reduced expression of the RUNX1 transcription factor that promotes myeloid cell development.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “In diabetes, the inflammatory response is prolonged and augmented over time, with increased myeloid cells present in the wound that fail to switch from a pro-inflammatory phenotype to a pro-healing phenotype.” | 0.93 | phenotype_alias_lexicon_v2 |