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SIRT1 and thalassemia are reported together in 2 articles.
Gene
SIRT1
- HGNC
- HGNC:14929
104articles
104mentions
6variants with confirmed gene link
Most co-reported phenotypes (articles)
diabetes mellitus 18ulcerative colitis 7breast cancer 5cardiomyopathy 5inflammatory bowel disease 5intellectual disability 5Parkinson disease 4obesity 4
Reported variants (articles · ClinVar status)
Phenotype
Thalassemia
- HPO
- HP:0001878
409articles
409mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Gut microbiota-derived TMAO and SIRT1/HMGB1 Axis: unveiling mechanisms of renal impairment in beta-thalassemia major.
PMID 39558119 | DOI 10.1038/s41390-024-03747-7 · Pediatric research · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SIRT1 | “Gut microbiota-derived TMAO and SIRT1/HMGB1 Axis: unveiling mechanisms of renal impairment in beta-thalassemia major.” | 0.98 | hgnc_dict_v1 |
| phenotype | thalassemia | “Gut microbiota-derived TMAO and SIRT1/HMGB1 Axis: unveiling mechanisms of renal impairment in beta-thalassemia major.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | HMGB1 | “Gut microbiota-derived TMAO and SIRT1/HMGB1 Axis: unveiling mechanisms of renal impairment in beta-thalassemia major.” | 0.98 | hgnc_dict_v1 |
Targeting SIRT1, NLRP3 inflammasome, and Nrf2 signaling with chrysin alleviates the iron-triggered hepatotoxicity in rats.
PMID 38432408 | DOI 10.1016/j.tox.2024.153766 · Toxicology · 2024 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SIRT1 | “Targeting SIRT1, NLRP3 inflammasome, and Nrf2 signaling with chrysin alleviates the iron-triggered hepatotoxicity in rats.” | 0.98 | hgnc_dict_v1 |
| phenotype | thalassemia | “Blood transfusion-requiring diseases such as sickle cell anemia and thalassemia are characterized by an imbalance between iron intake and excretion, resulting in an iron overload (IOL) disorder.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | NLRP3 | “Targeting SIRT1, NLRP3 inflammasome, and Nrf2 signaling with chrysin alleviates the iron-triggered hepatotoxicity in rats.” | 0.98 | hgnc_dict_v1 |
| phenotype | sickle cell anemia | “Blood transfusion-requiring diseases such as sickle cell anemia and thalassemia are characterized by an imbalance between iron intake and excretion, resulting in an iron overload (IOL) disorder.” | 0.98 | phenotype_alias_lexicon_v2 |