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SIRT3 and Parkinson disease are reported together in 2 articles.
Gene
SIRT3
- HGNC
- HGNC:14931
13articles
13mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Parkinson disease
280articles
280mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60System biology-based assessment of the molecular mechanism of epigallocatechin gallate in Parkinson's disease: via network pharmacology, in-silico evaluation & in-vitro studies.
PMID 40664965 | PMCID PMC12264099 | DOI 10.1038/s41598-025-11592-9 · Scientific reports · 2025 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SIRT3 | “Multiple targets such as SIRT3, FOXO1, PRKAA1, PPARGC1A, and CREBBP directly regulate reactive oxygen species levels and oxidative stress, suggesting that targeting these genes could help prevent further cellular damage.” | 0.98 | hgnc_dict_v1 |
| phenotype | Parkinson disease | “System biology-based assessment of the molecular mechanism of epigallocatechin gallate in Parkinson's disease: via network pharmacology, in-silico evaluation & in-vitro studies.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | FOXO1 | “Multiple targets such as SIRT3, FOXO1, PRKAA1, PPARGC1A, and CREBBP directly regulate reactive oxygen species levels and oxidative stress, suggesting that targeting these genes could help prevent further cellular damage.” | 0.98 | hgnc_dict_v1 |
| gene | PRKAA1 | “Multiple targets such as SIRT3, FOXO1, PRKAA1, PPARGC1A, and CREBBP directly regulate reactive oxygen species levels and oxidative stress, suggesting that targeting these genes could help prevent further cellular damage.” | 0.98 | hgnc_dict_v1 |
System biology-based assessment of the molecular mechanism of IMPHY000797 in Parkinson's disease: a network pharmacology and in-silico evaluation.
PMID 39379677 | PMCID PMC11461797 | DOI 10.1038/s41598-024-75603-x · Scientific reports · 2024 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SIRT3 | “Among the 25 proteins, the highest modulated genes and highest binding affinity were exhibited by SIRT3, FOXO1, and PPARGC1A with the compound IMPHY000797.” | 0.98 | hgnc_dict_v1 |
| phenotype | Parkinson disease | “System biology-based assessment of the molecular mechanism of IMPHY000797 in Parkinson's disease: a network pharmacology and in-silico evaluation.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | FOXO1 | “Among the 25 proteins, the highest modulated genes and highest binding affinity were exhibited by SIRT3, FOXO1, and PPARGC1A with the compound IMPHY000797.” | 0.98 | hgnc_dict_v1 |
| gene | PPARGC1A | “Among the 25 proteins, the highest modulated genes and highest binding affinity were exhibited by SIRT3, FOXO1, and PPARGC1A with the compound IMPHY000797.” | 0.98 | hgnc_dict_v1 |