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SIRT3 and cardiomyopathy are reported together in 2 articles.

Gene

SIRT3

13articles

13mentions

0variants with confirmed gene link

Most co-reported phenotypes (articles)

Phenotype

618articles

618mentions

12co-reported genes shown

Most co-reported genes (articles)

Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.

2 records shown · first 60

PMID 41496325 | DOI 10.1016/j.biopha.2025.118901 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026 · 5 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	SIRT3	“Notably, MTX upregulated cardiac SIRT3 and PFKFB3 expression while downregulating p53/TIGAR signaling pathways, indicating an improvement in T2D-induced glycolytic disruption and reduced apoptosis.”	0.98	hgnc_dict_v1
phenotype	cardiomyopathy	“Conclusively, MTX mitigates T2D-induced myocardial dysfunction by modulating SIRT3-related metabolic and inflammatory signaling pathways, highlighting its potential as a low-cost therapeutic option for diabetes-associated cardiomyopathy.”	0.98	phenotype_alias_lexicon_v2
gene	TIGAR	“Targeting the underlying immune mechanism of diabetes-induced myocardial dysfunction via modulation of SIRT-3/p53/TIGAR/PFKFB-3 and SIRT-3/NF-κB signaling pathways as a potential controlling strategy.”	0.98	hgnc_dict_v1
gene	PFKFB3	“Notably, MTX upregulated cardiac SIRT3 and PFKFB3 expression while downregulating p53/TIGAR signaling pathways, indicating an improvement in T2D-induced glycolytic disruption and reduced apoptosis.”	0.98	hgnc_dict_v1

PMID 39566866 | DOI 10.1016/j.cpcardiol.2024.102929 · Current problems in cardiology · 2025 · 4 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	SIRT3	“The Sirtuin (SIRT) family of NAD+-dependent enzymes has recently been shown to play a critical role in cardiovascular health and disease, and several SIRT isoforms, especially SIRT1 and SIRT3, have been amply investigated.”	0.98	hgnc_dict_v1
phenotype	cardiomyopathy	“Here, we review the current understanding of the involvement of SIRT2 in various cardiovascular pathologies, such as cardiac hypertrophy, ischemia-reperfusion injury, diabetic cardiomyopathy, and vascular dysfunction, with emphasis placed on the context-dependent protective or deleterious actions of SIRT2, including its wide array of catalytic activities which span beyond deacetylation.”	0.98	phenotype_alias_lexicon_v2
gene	SIRT2	“The enigmatic role of SIRT2 in the cardiovascular system: Deciphering its protective and detrimental actions to unlock new avenues for therapeutic intervention.”	0.98	hgnc_dict_v1
gene	SIRT1	“The Sirtuin (SIRT) family of NAD+-dependent enzymes has recently been shown to play a critical role in cardiovascular health and disease, and several SIRT isoforms, especially SIRT1 and SIRT3, have been amply investigated.”	0.98	hgnc_dict_v1