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SIRT3 and diabetes mellitus are reported together in 3 articles.
Gene
SIRT3
- HGNC
- HGNC:14931
13articles
13mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Targeting the underlying immune mechanism of diabetes-induced myocardial dysfunction via modulation of SIRT-3/p53/TIGAR/PFKFB-3 and SIRT-3/NF-κB signaling pathways as a potential controlling strategy.
PMID 41496325 | DOI 10.1016/j.biopha.2025.118901 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SIRT3 | “Notably, MTX upregulated cardiac SIRT3 and PFKFB3 expression while downregulating p53/TIGAR signaling pathways, indicating an improvement in T2D-induced glycolytic disruption and reduced apoptosis.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “The current study explored the potential of methotrexate (MTX) to target type 2 diabetes (T2D)-induced immune response and mitigate the associated myocardial dysfunction, focusing on the modulation of SIRT3-related pathways.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | TIGAR | “Targeting the underlying immune mechanism of diabetes-induced myocardial dysfunction via modulation of SIRT-3/p53/TIGAR/PFKFB-3 and SIRT-3/NF-κB signaling pathways as a potential controlling strategy.” | 0.98 | hgnc_dict_v1 |
| gene | PFKFB3 | “Notably, MTX upregulated cardiac SIRT3 and PFKFB3 expression while downregulating p53/TIGAR signaling pathways, indicating an improvement in T2D-induced glycolytic disruption and reduced apoptosis.” | 0.98 | hgnc_dict_v1 |
Gene Expression Profiling of Multiple Histone Deacetylases (HDAC) and Its Correlation with NRF2-Mediated Redox Regulation in the Pathogenesis of Diabetic Foot Ulcers.
PMID 33096729 | PMCID PMC7589955 | DOI 10.3390/biom10101466 · Biomolecules · 2020 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SIRT3 | “Of note, a significant upregulation of HDAC1, 3, 4, 11, SIRT3 and downregulation of HDAC2,8, SIRT1, SIRT2, SIRT3, SIRT7 among DFU patients were observed.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Attempting to unravel the epigenetic regulation of type 2 diabetes mellitus (T2DM) and diabetic foot ulcer (DFU), we profiled the expression of eleven isoform-specific histone deacetylases (HDACs) and correlated them with NRF2 and cytokines.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | HDAC1 | “Of note, a significant upregulation of HDAC1, 3, 4, 11, SIRT3 and downregulation of HDAC2,8, SIRT1, SIRT2, SIRT3, SIRT7 among DFU patients were observed.” | 0.98 | hgnc_dict_v1 |
| gene | HDAC2 | “Of note, a significant upregulation of HDAC1, 3, 4, 11, SIRT3 and downregulation of HDAC2,8, SIRT1, SIRT2, SIRT3, SIRT7 among DFU patients were observed.” | 0.98 | hgnc_dict_v1 |
The expression of sirtuins, superoxide dismutase, and lipid peroxidation status in peripheral blood from patients with diabetes and hypothyroidism.
PMID 30736780 | PMCID PMC6368800 | DOI 10.1186/s12902-019-0350-y · BMC endocrine disorders · 2019 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SIRT3 | “BACKGROUND: Sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3) proteins have an important role in counteracting oxidative stress.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “The expression of sirtuins, superoxide dismutase, and lipid peroxidation status in peripheral blood from patients with diabetes and hypothyroidism.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | SIRT1 | “BACKGROUND: Sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3) proteins have an important role in counteracting oxidative stress.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “This study investigated the effects of type 1 diabetes (T1D), type 2 diabetes (T2D), and HT on the expression levels of SIRT1, SIRT3, and manganese superoxide dismutase (SOD2).” | 0.98 | hgnc_dict_v1 |