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SLCO1B1 and rheumatoid arthritis are reported together in 2 articles.
Gene
SLCO1B1
- HGNC
- HGNC:10959
15articles
15mentions
4variants with confirmed gene link
Most co-reported phenotypes (articles)
congenital myopathy 4diabetes mellitus 2rheumatoid arthritis 2cystic fibrosis 1dyslipidemia 1familial hypercholesterolemia 1hepatitis C 1hepatocellular carcinoma 1
Reported variants (articles · ClinVar status)
Phenotype
Rheumatoid arthritis
212articles
212mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Unveiling the heritability of selected unexplored pharmacogenetic markers in the Saudi population.
PMID 40376268 | PMCID PMC12078325 | DOI 10.3389/fphar.2025.1559399 · Frontiers in pharmacology · 2025 · 34 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SLCO1B1 | “Another three markers [rs16969968 in CHRNA5, rs11881222 in IFNL3 (IL28B), and SLCO1B1*14] were found to be highly distributed among the participants (MAF = 0.35, 0.30, and 0.14, respectively).” | 0.98 | hgnc_dict_v1 |
| phenotype | rheumatoid arthritis | “The findings have implications for personalizing treatments for various conditions, including rheumatoid arthritis, cystic fibrosis, and hepatitis C.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | DPYD | “The selected variants in six genes [DPYD (rs1801268), CACNA1S (rs772226819), EGFR (rs121434568), RYR1 (rs193922816), CYP2B6 (rs3826711), and MT-RNR1 (rs267606617, rs267606618, rs267606619)] were found to be non-existing among Saudis.” | 0.98 | hgnc_dict_v1 |
| gene | CACNA1S | “The selected variants in six genes [DPYD (rs1801268), CACNA1S (rs772226819), EGFR (rs121434568), RYR1 (rs193922816), CYP2B6 (rs3826711), and MT-RNR1 (rs267606617, rs267606618, rs267606619)] were found to be non-existing among Saudis.” | 0.98 | hgnc_dict_v1 |
Association of SLCO1B3 and SLCO1B1 Polymorphisms with Methotrexate Efficacy and Toxicity in Saudi Rheumatoid Arthritis Patients.
PMID 40732356 | PMCID PMC12299335 | DOI 10.3390/ph18071069 · Pharmaceuticals (Basel, Switzerland) · 2025 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SLCO1B1 | “Association of SLCO1B3 and SLCO1B1 Polymorphisms with Methotrexate Efficacy and Toxicity in Saudi Rheumatoid Arthritis Patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | rheumatoid arthritis | “Association of SLCO1B3 and SLCO1B1 Polymorphisms with Methotrexate Efficacy and Toxicity in Saudi Rheumatoid Arthritis Patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SLCO1B3 | “Association of SLCO1B3 and SLCO1B1 Polymorphisms with Methotrexate Efficacy and Toxicity in Saudi Rheumatoid Arthritis Patients.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia, Jeddah | “Association of SLCO1B3 and SLCO1B1 Polymorphisms with Methotrexate Efficacy and Toxicity in Saudi Rheumatoid Arthritis Patients. However, research on these polymorphisms in Saudi Arabia remains limited. We evaluated the association of SLCO1B3 (rs4149117, rs7311358) and SLCO1B1 (rs2306283, rs4149056) polymorphisms with MTX efficacy and safety in Saudi patients with RA. Methods: This multicenter, case-control study included patients diagnosed with RA in Jeddah and Taif. Results: The study cohort comprised 100 patients with RA, with 46 showing a good response to MTX and 54 showing a poor response.” | 0.95 | saudi_context_rules_v1 |