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SOD1 and breast cancer are reported together in 3 articles.
Gene
SOD1
- HGNC
- HGNC:11179
60articles
60mentions
3variants with confirmed gene link
Most co-reported phenotypes (articles)
amyotrophic lateral sclerosis 16diabetes mellitus 4breast cancer 3obesity 3Alzheimer disease 2Parkinson disease 2hepatocellular carcinoma 2lung cancer 2
Reported variants (articles · ClinVar status)
Phenotype
Breast cancer
1,211articles
1,211mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Assessing the Association Between Genetic Variants in ACE, SOD1, and PER3 and their Role in Breast Cancer Risk among Jordanian Women.
PMID 42327579 | PMCID PMC13280626 | DOI 10.7150/jca.133243 · Journal of Cancer · 2026 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SOD1 | “Assessing the Association Between Genetic Variants in ACE, SOD1, and PER3 and their Role in Breast Cancer Risk among Jordanian Women.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Assessing the Association Between Genetic Variants in ACE, SOD1, and PER3 and their Role in Breast Cancer Risk among Jordanian Women.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ACE | “Assessing the Association Between Genetic Variants in ACE, SOD1, and PER3 and their Role in Breast Cancer Risk among Jordanian Women.” | 0.98 | hgnc_dict_v1 |
| gene | PER3 | “Assessing the Association Between Genetic Variants in ACE, SOD1, and PER3 and their Role in Breast Cancer Risk among Jordanian Women.” | 0.98 | hgnc_dict_v1 |
Synthesis and multilevel evaluation of benzimidazole-based anticancer compounds: DNA/serum albumin interaction, and in-depth theoretical insights.
PMID 42334525 | PMCID PMC13524987 | DOI 10.1007/s11010-026-05600-3 · Molecular and cellular biochemistry · 2026 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SOD1 | “Also, to elucidate the anticancer mechanism of compounds, pro-apoptotic BAX and BiD, anti-apoptotic BCL2 and BCL-xl, oxidant enzymes PRDX1 and SOD1 levels were examined by RT-qPCR.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Compounds 3a and 3b were tested utilizing the MTT study to evaluate their in vitro cytotoxic activity against healthy human embryonic kidney, lung cancer, breast cancer, and human liver cancer cell lines.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BCL2 | “Also, to elucidate the anticancer mechanism of compounds, pro-apoptotic BAX and BiD, anti-apoptotic BCL2 and BCL-xl, oxidant enzymes PRDX1 and SOD1 levels were examined by RT-qPCR.” | 0.98 | hgnc_dict_v1 |
| gene | PRDX1 | “Also, to elucidate the anticancer mechanism of compounds, pro-apoptotic BAX and BiD, anti-apoptotic BCL2 and BCL-xl, oxidant enzymes PRDX1 and SOD1 levels were examined by RT-qPCR.” | 0.98 | hgnc_dict_v1 |
Effectiveness of Nonfunctionalized Graphene Oxide Nanolayers as Nanomedicine against Colon, Cervical, and Breast Cancer Cells.
PMID 37298090 | PMCID PMC10252622 | DOI 10.3390/ijms24119141 · International journal of molecular sciences · 2023 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SOD1 | “The qPCR quantification showed the upregulation of caspase 3, caspase 9, bax, and SOD1 genes in GRO-NLs-treated cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Effectiveness of Nonfunctionalized Graphene Oxide Nanolayers as Nanomedicine against Colon, Cervical, and Breast Cancer Cells.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CDC25C | “Western blotting showed the depletion of P21, P53, and CDC25C proteins in the above cancer cell lines after GRO-NLs treatment, indicating its function as a mutagen to induce mutation in the P53 gene, thereby affecting P53 protein and downstream effectors P21 and CDC25C.” | 0.98 | hgnc_dict_v1 |