Type	Entity	Source evidence	Confidence	Extractor
gene	SOD1	“Gene expression of catalase, superoxide dismutase (SOD1, SOD2), and glutathione peroxidase (GPx) are changed twice, thrice, and quadruplet, respectively.”	0.98	hgnc_dict_v1
phenotype	diabetes mellitus	“To date, there is no satisfactory and effective therapy available to cure type 2 diabetes mellitus (T2DM).”	0.98	phenotype_alias_lexicon_v2
gene	SOD2	“Gene expression of catalase, superoxide dismutase (SOD1, SOD2), and glutathione peroxidase (GPx) are changed twice, thrice, and quadruplet, respectively.”	0.98	hgnc_dict_v1
gene	TET1	“The level of interleukin-1 (IL1) and tumor necrosis factor-α (TNF-α) was restored but the interleukin-6 (IL6) and ten-eleven-translocation-1 (TET1) were completely knocked down by the use of saroglitazar.”	0.98	hgnc_dict_v1

PMID 35987163 | DOI 10.1016/j.biopha.2022.113554 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022 · 4 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	SOD1	“Evaluation of each group was via histopathological examination, assessment of gene and/or protein expression concerned with oxidative stress (SOD1, SOD2, Nox2, Nox4, iNOS), inflammation (TNF-α, ICAM-1, NF-κB) and angiogenesis (VEGF, VE-cadherin).”	0.98	hgnc_dict_v1
phenotype	diabetes mellitus	“BACKGROUND: Diabetic retinopathy (DR) is a serious microvascular complication of diabetes mellitus.”	0.98	phenotype_alias_lexicon_v2
gene	DKK1	“METHODS: Eighty-one rats were allocated into 6 groups (control, DR, DR + DKK1, DR + exosomes, DR + Wnt3a and DR + exosomes+Wnt3a).”	0.98	hgnc_dict_v1
gene	SOD2	“Evaluation of each group was via histopathological examination, assessment of gene and/or protein expression concerned with oxidative stress (SOD1, SOD2, Nox2, Nox4, iNOS), inflammation (TNF-α, ICAM-1, NF-κB) and angiogenesis (VEGF, VE-cadherin).”	0.98	hgnc_dict_v1

PMID 34725640 | PMCID PMC8557063 | DOI 10.1155/2021/6978450 · BioMed research international · 2021 · 27 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	SOD1	“Following intervention, blood serum was examined for biochemical markers, and liver tissue was investigated for the mRNA expression of catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD1) by RTPCR analysis.”	0.98	hgnc_dict_v1
phenotype	diabetes mellitus	“Pathway analysis identified 31 KEGG metabolic, signaling, and immunogenic pathways associated with diabetes.”	0.93	phenotype_alias_lexicon_v2
gene	AKR1B10	“Oleanolic acid interacted with the proteins AKR1B10, CASP3, CASP8, CYP1A2, CYP1A2, HMGB1, NAMPT, NFE2L2, NQO1, PPARA, PTGIR, TOP1, TOP2A, UGT2B10, and UGT2B11 and stigmasterol with ABCA1, ABCG5, ABCG8, CTSE, HMGCR, IL10, CXCL8, NR1H2, NR1H3, SLCO1B1, SREBF2, and TNF.”	0.98	hgnc_dict_v1
gene	CASP3	“Oleanolic acid interacted with the proteins AKR1B10, CASP3, CASP8, CYP1A2, CYP1A2, HMGB1, NAMPT, NFE2L2, NQO1, PPARA, PTGIR, TOP1, TOP2A, UGT2B10, and UGT2B11 and stigmasterol with ABCA1, ABCG5, ABCG8, CTSE, HMGCR, IL10, CXCL8, NR1H2, NR1H3, SLCO1B1, SREBF2, and TNF.”	0.98	hgnc_dict_v1

PMID 29724198 | PMCID PMC5934787 | DOI 10.1186/s12933-018-0709-9 · Cardiovascular diabetology · 2018 · 4 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	SOD1	“Gene expression analysis showed an upregulation in CD34+ cells for antioxidant SOD1 (p < 0.05) and a downregulation in CD34- cells for IL-6 (p < 0.01).”	0.98	hgnc_dict_v1
phenotype	diabetes mellitus	“The synergistic effects of saxagliptin and metformin on CD34+ endothelial progenitor cells in early type 2 diabetes patients: a randomized clinical trial.”	0.93	phenotype_alias_lexicon_v2
gene	CD34	“The synergistic effects of saxagliptin and metformin on CD34+ endothelial progenitor cells in early type 2 diabetes patients: a randomized clinical trial.”	0.98	hgnc_dict_v1
gene	CXCR4	“MNCs cytometry showed higher percentage of CXCR4 double positivity for both CD34 and CD31 positive cells, indicating a functional improvement.”	0.98	hgnc_dict_v1