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SOD1 and hepatocellular carcinoma are reported together in 2 articles.
Gene
SOD1
- HGNC
- HGNC:11179
60articles
60mentions
3variants with confirmed gene link
Most co-reported phenotypes (articles)
amyotrophic lateral sclerosis 16diabetes mellitus 4breast cancer 3obesity 3Alzheimer disease 2Parkinson disease 2hepatocellular carcinoma 2lung cancer 2
Reported variants (articles · ClinVar status)
Phenotype
Hepatocellular carcinoma
417articles
417mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Synthesis and multilevel evaluation of benzimidazole-based anticancer compounds: DNA/serum albumin interaction, and in-depth theoretical insights.
PMID 42334525 | PMCID PMC13524987 | DOI 10.1007/s11010-026-05600-3 · Molecular and cellular biochemistry · 2026 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SOD1 | “Also, to elucidate the anticancer mechanism of compounds, pro-apoptotic BAX and BiD, anti-apoptotic BCL2 and BCL-xl, oxidant enzymes PRDX1 and SOD1 levels were examined by RT-qPCR.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Compounds 3a and 3b were tested utilizing the MTT study to evaluate their in vitro cytotoxic activity against healthy human embryonic kidney, lung cancer, breast cancer, and human liver cancer cell lines.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | BCL2 | “Also, to elucidate the anticancer mechanism of compounds, pro-apoptotic BAX and BiD, anti-apoptotic BCL2 and BCL-xl, oxidant enzymes PRDX1 and SOD1 levels were examined by RT-qPCR.” | 0.98 | hgnc_dict_v1 |
| gene | PRDX1 | “Also, to elucidate the anticancer mechanism of compounds, pro-apoptotic BAX and BiD, anti-apoptotic BCL2 and BCL-xl, oxidant enzymes PRDX1 and SOD1 levels were examined by RT-qPCR.” | 0.98 | hgnc_dict_v1 |
Nickel Oxide Nanoparticles Induced Transcriptomic Alterations in HEPG2 Cells.
PMID 29453538 | DOI 10.1007/978-3-319-72041-8_10 · Advances in experimental medicine and biology · 2018 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SOD1 | “Real-time PCR analysis of apoptotic (p53, bax, bcl2) and oxidative stress (SOD1) genes showed transcriptional upregulation.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “In this study, we integrated transcriptomic approach and genotoxic evidence to depict the mechanism of NiO-NPs toxicity in human hepatocellular carcinoma (HepG2) cells.” | 0.98 | phenotype_alias_lexicon_v2 |