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SOD1 and lung cancer are reported together in 2 articles.
Gene
SOD1
- HGNC
- HGNC:11179
60articles
60mentions
3variants with confirmed gene link
Most co-reported phenotypes (articles)
amyotrophic lateral sclerosis 16diabetes mellitus 4breast cancer 3obesity 3Alzheimer disease 2Parkinson disease 2hepatocellular carcinoma 2lung cancer 2
Reported variants (articles · ClinVar status)
Phenotype
Lung cancer
398articles
398mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Synthesis and multilevel evaluation of benzimidazole-based anticancer compounds: DNA/serum albumin interaction, and in-depth theoretical insights.
PMID 42334525 | PMCID PMC13524987 | DOI 10.1007/s11010-026-05600-3 · Molecular and cellular biochemistry · 2026 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SOD1 | “Also, to elucidate the anticancer mechanism of compounds, pro-apoptotic BAX and BiD, anti-apoptotic BCL2 and BCL-xl, oxidant enzymes PRDX1 and SOD1 levels were examined by RT-qPCR.” | 0.98 | hgnc_dict_v1 |
| phenotype | lung cancer | “Compounds 3a and 3b were tested utilizing the MTT study to evaluate their in vitro cytotoxic activity against healthy human embryonic kidney, lung cancer, breast cancer, and human liver cancer cell lines.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BCL2 | “Also, to elucidate the anticancer mechanism of compounds, pro-apoptotic BAX and BiD, anti-apoptotic BCL2 and BCL-xl, oxidant enzymes PRDX1 and SOD1 levels were examined by RT-qPCR.” | 0.98 | hgnc_dict_v1 |
| gene | PRDX1 | “Also, to elucidate the anticancer mechanism of compounds, pro-apoptotic BAX and BiD, anti-apoptotic BCL2 and BCL-xl, oxidant enzymes PRDX1 and SOD1 levels were examined by RT-qPCR.” | 0.98 | hgnc_dict_v1 |
Liquid mosquito repellent induces toxic effects in zebrafish.
PMID 39686665 | DOI 10.1080/01480545.2024.2436511 · Drug and chemical toxicology · 2025 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SOD1 | “Analysis of gene expression demonstrated significant dysregulation in genes associated with oxidative stress (SOD1, CAT), inflammatory markers (TNF-α, IL-1β), apoptotic regulators (p53, bcl2), and neurobiological genes (brain-derived neurotrophic factor, bdnf).” | 0.98 | hgnc_dict_v1 |
| phenotype | lung cancer | “The analysis of network toxicology indicated that 78 of the examined compounds contravened Lipinski's rule of five and exhibited considerable overlap with target genes associated with lung cancer pathways, thereby highlighting potential concerns regarding their carcinogenic properties.” | 0.98 | phenotype_alias_lexicon_v2 |