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SOD1 and obesity are reported together in 3 articles.
Gene
SOD1
- HGNC
- HGNC:11179
60articles
60mentions
3variants with confirmed gene link
Most co-reported phenotypes (articles)
amyotrophic lateral sclerosis 16diabetes mellitus 4breast cancer 3obesity 3Alzheimer disease 2Parkinson disease 2hepatocellular carcinoma 2lung cancer 2
Reported variants (articles · ClinVar status)
Phenotype
Obesity
- HPO
- HP:0001513
856articles
856mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Resveratrol Anti-inflammatory Effect against Palmitate-induced Cytotoxicity in Raw 264.7 Macrophages.
PMID 39819539 | DOI 10.2174/0109298673352457241210083325 · Current medicinal chemistry · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SOD1 | “RES was shown to mitigate the effect of PA on macrophages bioenergetics and the oxidative damage and counteracted PA effect on genes linked to oxidative damage, such as Nrf2, Ho-1, NF-κB p65, SOD1, and SOD2.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “CONCLUSION: RES could reduce PA-induced lipotoxicity in macrophages via enhancing their viability and counteracting the excess release of cytokines through alleviating PAinduced bioenergetic disruption and oxidative damage with a suggested positive impact of RES on obesity related illnesses caused by triggered cellular inflammation.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SOD2 | “RES was shown to mitigate the effect of PA on macrophages bioenergetics and the oxidative damage and counteracted PA effect on genes linked to oxidative damage, such as Nrf2, Ho-1, NF-κB p65, SOD1, and SOD2.” | 0.98 | hgnc_dict_v1 |
Antidiabetic Effect of Tamarindus indica and Momordica charantia and Downregulation of TET-1 Gene Expression by Saroglitazar in Glucose Feed Adipocytes and Their Involvement in the Type 2 Diabetes-Associated Inflammation In Vitro.
PMID 35832850 | PMCID PMC9273433 | DOI 10.1155/2022/9565136 · BioMed research international · 2022 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SOD1 | “Gene expression of catalase, superoxide dismutase (SOD1, SOD2), and glutathione peroxidase (GPx) are changed twice, thrice, and quadruplet, respectively.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “The purpose of this study is to examine new ideas and approaches for treating obesity, T2DM, and other associated metabolic disorders.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SOD2 | “Gene expression of catalase, superoxide dismutase (SOD1, SOD2), and glutathione peroxidase (GPx) are changed twice, thrice, and quadruplet, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | TET1 | “The level of interleukin-1 (IL1) and tumor necrosis factor-α (TNF-α) was restored but the interleukin-6 (IL6) and ten-eleven-translocation-1 (TET1) were completely knocked down by the use of saroglitazar.” | 0.98 | hgnc_dict_v1 |
Antioxidants-Related Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPX), Glutathione-S-Transferase (GST), and Nitric Oxide Synthase (NOS) Gene Variants Analysis in an Obese Population: A Preliminary Case-Control Study.
PMID 33924357 | PMCID PMC8070436 | DOI 10.3390/antiox10040595 · Antioxidants (Basel, Switzerland) · 2021 · 14 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SOD1 | “Six SNPs were significantly more prevalent in obese cohorts: (1) GSTM1 rs1056806*C/T; (2) SOD1 rs2234694*A; (3) SOD2 rs4880*G; (4) SOD3 rs2536512*A; (5) GPX1 rs1800668*A; (6) NOS3 rs1799983*G.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Oxidative stress and antioxidants play an important role in obesity etiopathology.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | GSTM1 | “Six SNPs were significantly more prevalent in obese cohorts: (1) GSTM1 rs1056806*C/T; (2) SOD1 rs2234694*A; (3) SOD2 rs4880*G; (4) SOD3 rs2536512*A; (5) GPX1 rs1800668*A; (6) NOS3 rs1799983*G.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Six SNPs were significantly more prevalent in obese cohorts: (1) GSTM1 rs1056806*C/T; (2) SOD1 rs2234694*A; (3) SOD2 rs4880*G; (4) SOD3 rs2536512*A; (5) GPX1 rs1800668*A; (6) NOS3 rs1799983*G.” | 0.98 | hgnc_dict_v1 |