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STAT1 and multiple sclerosis are reported together in 1 article.
Gene
STAT1
- HGNC
- HGNC:11362
51articles
51mentions
10variants with confirmed gene link (top 10)
Most co-reported phenotypes (articles)
COVID-19 5autism spectrum disorder 5diabetes mellitus 5tuberculosis 3neurodevelopmental disorder 2systemic lupus erythematosus 2Alzheimer disease 1MERS 1
Reported variants (articles · ClinVar status)
Phenotype
Multiple sclerosis
236articles
236mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60MAPK pathway and B cells overactivation in multiple sclerosis revealed by phosphoproteomics and genomic analysis.
PMID 31004050 | PMCID PMC6510997 | DOI 10.1073/pnas.1818347116 · Proceedings of the National Academy of Sciences of the United States of America · 2019 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | STAT1 | “Finally, using flow cytometry, we detected in MS patients increased STAT1, STAT3, TF65, and HSPB1 phosphorylation in CD19+ cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | multiple sclerosis | “MAPK pathway and B cells overactivation in multiple sclerosis revealed by phosphoproteomics and genomic analysis.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | IRF8 | “Moreover, we identified one SNP located in the PHDGH gene and another on IRF8 gene that were associated with MP2K1 phosphorylation levels, providing a first clue on how this MS risk gene may act.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Finally, using flow cytometry, we detected in MS patients increased STAT1, STAT3, TF65, and HSPB1 phosphorylation in CD19+ cells.” | 0.98 | hgnc_dict_v1 |