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STAT1 and tuberculosis are reported together in 3 articles.
Gene
STAT1
- HGNC
- HGNC:11362
51articles
51mentions
10variants with confirmed gene link (top 10)
Most co-reported phenotypes (articles)
COVID-19 5autism spectrum disorder 5diabetes mellitus 5tuberculosis 3neurodevelopmental disorder 2systemic lupus erythematosus 2Alzheimer disease 1MERS 1
Reported variants (articles · ClinVar status)
Phenotype
Tuberculosis
405articles
405mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Identification and Analysis of Autophagy-Related Genes as Diagnostic Markers and Potential Therapeutic Targets for Tuberculosis Through Bioinformatics.
PMID 39618249 | DOI 10.1089/dna.2024.0166 · DNA and cell biology · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | STAT1 | “Interleukin 1B (IL1B), CAPS1, and signal transducer and activator of transcription 1 (STAT1) were identified by intersection out of 22 DE-ATGs discovered by differential expression analysis.” | 0.98 | hgnc_dict_v1 |
| phenotype | tuberculosis | “Identification and Analysis of Autophagy-Related Genes as Diagnostic Markers and Potential Therapeutic Targets for Tuberculosis Through Bioinformatics.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | IL1B | “Interleukin 1B (IL1B), CAPS1, and signal transducer and activator of transcription 1 (STAT1) were identified by intersection out of 22 DE-ATGs discovered by differential expression analysis.” | 0.98 | hgnc_dict_v1 |
| gene | CASP1 | “We found that IL1B, CASP1, and STAT1 are important biomarkers for TB.” | 0.98 | hgnc_dict_v1 |
Novel mutations in genes of the IL-12/IFN-γ axis cause susceptibility to tuberculosis.
PMID 37437430 | DOI 10.1016/j.jiph.2023.06.005 · Journal of infection and public health · 2023 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | STAT1 | “Flow cytometry was used to detect the surface expressions of IFN-γR1 and IFN-γR2 as well as IL-12Rβ1and IL-12Rβ2 on monocytes and T lymphocytes, respectively.The phosphorylation of signal transducer and activator of transcription 1(STAT1) on monocytes and STAT4 on T lymphocytes were also detected by flow cytometry.” | 0.98 | hgnc_dict_v1 |
| phenotype | tuberculosis | “Novel mutations in genes of the IL-12/IFN-γ axis cause susceptibility to tuberculosis.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | STAT4 | “Flow cytometry was used to detect the surface expressions of IFN-γR1 and IFN-γR2 as well as IL-12Rβ1and IL-12Rβ2 on monocytes and T lymphocytes, respectively.The phosphorylation of signal transducer and activator of transcription 1(STAT1) on monocytes and STAT4 on T lymphocytes were also detected by flow cytometry.” | 0.98 | hgnc_dict_v1 |
| gene | CYBB | “Sanger sequencing was used to identify mutations in the IL-12Rβ1, STAT1, NEMO, and CYBB genes.” | 0.98 | hgnc_dict_v1 |
A Network-Based Analysis Reveals the Mechanism Underlying Vitamin D in Suppressing Cytokine Storm and Virus in SARS-CoV-2 Infection.
PMID 33362771 | PMCID PMC7756074 | DOI 10.3389/fimmu.2020.590459 · Frontiers in immunology · 2020 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | STAT1 | “Interestingly, the iRegulone tool identified that "Cluster 1" is under the regulation of transcription factors STAT1, STAT2, STAT3, POU2F2, and NFkB1, collectively referred to as "host response signature network".” | 0.98 | hgnc_dict_v1 |
| phenotype | tuberculosis | “Functional enrichment analysis with NDEx revealed that the "host response signature network" is predominantly associated with critical pathways, including "cytokines and inflammatory response", "non-genomic action of Vitamin D", "the human immune response to tuberculosis", and "lung fibrosis".” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | STAT2 | “Interestingly, the iRegulone tool identified that "Cluster 1" is under the regulation of transcription factors STAT1, STAT2, STAT3, POU2F2, and NFkB1, collectively referred to as "host response signature network".” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Interestingly, the iRegulone tool identified that "Cluster 1" is under the regulation of transcription factors STAT1, STAT2, STAT3, POU2F2, and NFkB1, collectively referred to as "host response signature network".” | 0.98 | hgnc_dict_v1 |