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STAT3 and cardiomyopathy are reported together in 2 articles.
Gene
STAT3
- HGNC
- HGNC:11364
206articles
206mentions
4variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 25hepatocellular carcinoma 13lung cancer 13colorectal cancer 12diabetes mellitus 12autism spectrum disorder 11ulcerative colitis 9neurodevelopmental disorder 8
Reported variants (articles · ClinVar status)
Phenotype
Cardiomyopathy
- HPO
- HP:0001638
618articles
618mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Uncovering dendritic cell specific biomarkers for diagnosis and prognosis of cardiomyopathy using single cell RNA sequencing and comprehensive bioinformatics analysis.
PMID 40419517 | PMCID PMC12106800 | DOI 10.1038/s41598-024-78011-3 · Scientific reports · 2025 · 10 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | STAT3 | “Following that, several transcription factors (GATA2, FOXC1, SREBF1, STAT3, and NFKB1) as well as microRNA (hsa-mir-26a-5p, hsa-mir-129-2-3p, etc.) were predicted.” | 0.98 | hgnc_dict_v1 |
| phenotype | cardiomyopathy | “Uncovering dendritic cell specific biomarkers for diagnosis and prognosis of cardiomyopathy using single cell RNA sequencing and comprehensive bioinformatics analysis.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ITGAX | “The protein-protein interaction (PPI) network revealed five key hub proteins (ITGAX, IRF7, MX1, HLA-B, and IRF1).” | 0.98 | hgnc_dict_v1 |
| gene | IRF7 | “The protein-protein interaction (PPI) network revealed five key hub proteins (ITGAX, IRF7, MX1, HLA-B, and IRF1).” | 0.98 | hgnc_dict_v1 |
Mesenchymal stem cells improve cardiac function in diabetic rats by reducing cardiac injury biomarkers and downregulating JAK/STAT/iNOS and iNOS/Apoptosis signaling pathways.
PMID 38797354 | DOI 10.1016/j.mce.2024.112280 · Molecular and cellular endocrinology · 2024 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | STAT3 | “Administration of MSCs improved dyslipidemia, the altered cardiac injury biomarkers (p ≤ 0.0001), downregulated Janus kinase 2/signal transducer and activator of transcription 3(JAK2/STAT3)/inducible Nitric oxide synthase (iNOS) and iNOS/Apoptosis signaling pathways.” | 0.98 | hgnc_dict_v1 |
| phenotype | cardiomyopathy | “Our results show that MSCs ameliorate cardiac dysfunction associated with diabetic cardiomyopathy by lowering dyslipidemia and insulin resistance, inhibiting oxidative stress, and inflammation, downregulating JAK2/STAT3/iNOS and iNOS/Apoptosis signaling pathways.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | JAK2 | “Administration of MSCs improved dyslipidemia, the altered cardiac injury biomarkers (p ≤ 0.0001), downregulated Janus kinase 2/signal transducer and activator of transcription 3(JAK2/STAT3)/inducible Nitric oxide synthase (iNOS) and iNOS/Apoptosis signaling pathways.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Cardiovascular complications are prevalent manifestations of type 2 diabetes mellitus (T2DM) and are usually the main cause of death.” | 0.98 | phenotype_alias_lexicon_v2 |