Type	Entity	Source evidence	Confidence	Extractor
gene	STAT3	“Notably, BTK-high tumors showed robust enrichment of immune pathways (interferon gamma (IFN-γ) response, interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3), tumor necrosis factor-α (TNF-α) signaling) and exhibited elevated tumor-infiltrating leukocyte and lymphocyte fractions, increased cytolytic activity, and greater abundance of myeloid and lymphoid cell populations.”	0.98	hgnc_dict_v1
phenotype	lymphoma	“BTK inhibitors are approved and in clinical use for hematological cancers such as lymphoma and leukemia, with testing underway in solid tumors.”	0.98	phenotype_alias_lexicon_v2
phenotype	breast cancer	“Expression of Bruton's Tyrosine Kinase Reflects Immune Cells Infiltration and Cell Proliferation in Breast Cancer.”	0.98	phenotype_alias_lexicon_v2
phenotype	leukemia	“BTK inhibitors are approved and in clinical use for hematological cancers such as lymphoma and leukemia, with testing underway in solid tumors.”	0.98	phenotype_alias_lexicon_v2

PMID 36287175 | PMCID PMC9898117 | DOI 10.1158/1541-7786.MCR-19-1209 · Molecular cancer research : MCR · 2023 · 6 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	STAT3	“Gut-derived Endotoxin-TLR4 Signaling Drives MYC-Ig Translocation to Promote Lymphoproliferation through c-JUN and STAT3 Activation.”	0.98	hgnc_dict_v1
phenotype	lymphoma	“UNLABELLED: Synergism between obesity and virus infection promotes the development of B-cell lymphoma.”	0.98	phenotype_alias_lexicon_v2
gene	TLR4	“TLR4 activation in turn caused c-JUN-dependent and STAT3-dependent translocations of MYC loci to suppress transactivation of CD95/FAS.”	0.98	hgnc_dict_v1
gene	MYC	“TLR4 activation in turn caused c-JUN-dependent and STAT3-dependent translocations of MYC loci to suppress transactivation of CD95/FAS.”	0.98	hgnc_dict_v1

PMID 32327503 | PMCID PMC8168516 | DOI 10.3324/haematol.2019.238766 · Haematologica · 2021 · 5 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	STAT3	“Furthermore, we demonstrate that NPM-ALK promotes NOTCH1 expression through binding of STAT3 upstream of NOTCH1.”	0.98	hgnc_dict_v1
phenotype	lymphoma	“Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target.”	0.98	phenotype_alias_lexicon_v2
gene	NOTCH1	“Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target.”	0.98	hgnc_dict_v1
gene	ALK	“To understand disease pathology and to uncover novel targets for therapy, Whole-Exome Sequencing (WES) of Anaplastic Lymphoma Kinase (ALK)+ ALCL was performed as well as Gene-Set Enrichment Analysis.”	0.98	hgnc_dict_v1

PMID 32183146 | PMCID PMC7144730 | DOI 10.3390/molecules25061320 · Molecules (Basel, Switzerland) · 2020 · 3 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	STAT3	“We investigated the ability of EVO to affect hepatocyte growth factor (HGF)-induced c-Met/Src/STAT3 activation cascades in castration-resistant prostate cancer (CRPC).”	0.98	hgnc_dict_v1
phenotype	lymphoma	“Then, we noted that EVO arrested the cell cycle, caused apoptosis, and downregulated the expression of various carcinogenic markers such as B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-xL), cyclin D1, cyclooxygenase 2 (COX-2), survivin, vascular endothelial growth factor (VEGF), and matrix metallopeptidases 9 (MMP-9).”	0.98	phenotype_alias_lexicon_v2
phenotype	prostate cancer	“Evodiamine Mitigates Cellular Growth and Promotes Apoptosis by Targeting the c-Met Pathway in Prostate Cancer Cells.”	0.98	phenotype_alias_lexicon_v2

PMID 26062544 | PMCID PMC4477598 | DOI 10.1186/s40659-015-0022-y · Biological research · 2015 · 4 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	STAT3	“Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats.”	0.98	hgnc_dict_v1
phenotype	lymphoma	“Expression of the following genes were monitored with real-time PCR: interleukin-6 (IL-6), dual-specificity protein kinase 5 (MEK5), Fas-associated death domain protein (FADD), epidermal growth factor (EGF), signal transducer and activator of transcription 3 (STAT3), Janus kinase (JAK), B-cell lymphoma 2 (Bcl2) and B-cell lymphoma-extra-large (Bcl-XL).”	0.98	phenotype_alias_lexicon_v2
gene	FADD	“Expression of the following genes were monitored with real-time PCR: interleukin-6 (IL-6), dual-specificity protein kinase 5 (MEK5), Fas-associated death domain protein (FADD), epidermal growth factor (EGF), signal transducer and activator of transcription 3 (STAT3), Janus kinase (JAK), B-cell lymphoma 2 (Bcl2) and B-cell lymphoma-extra-large (Bcl-XL).”	0.98	hgnc_dict_v1
gene	EGF	“Expression of the following genes were monitored with real-time PCR: interleukin-6 (IL-6), dual-specificity protein kinase 5 (MEK5), Fas-associated death domain protein (FADD), epidermal growth factor (EGF), signal transducer and activator of transcription 3 (STAT3), Janus kinase (JAK), B-cell lymphoma 2 (Bcl2) and B-cell lymphoma-extra-large (Bcl-XL).”	0.98	hgnc_dict_v1