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STAT3 and metabolic syndrome are reported together in 3 articles.
Gene
STAT3
- HGNC
- HGNC:11364
206articles
206mentions
4variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 25hepatocellular carcinoma 13lung cancer 13colorectal cancer 12diabetes mellitus 12autism spectrum disorder 11ulcerative colitis 9neurodevelopmental disorder 8
Reported variants (articles · ClinVar status)
Phenotype
Metabolic syndrome
141articles
141mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Unlocking potentials of a prenylated flavonoid: Xanthohumol's role in combating inflammatory conditions and Rhematic diseases.
PMID 41429078 | DOI 10.1016/j.cyto.2025.157092 · Cytokine · 2026 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | STAT3 | “This review highlights xanthohumol's ability to modulate key signaling pathways, including NF-κB, STAT3, and Nrf2, which are central to inflammation, oxidative stress, and cancer progression.” | 0.98 | hgnc_dict_v1 |
| phenotype | metabolic syndrome | “It improves glucose homeostasis, lipid metabolism, and gut microbiota composition, offering therapeutic benefits for metabolic syndrome and diabetes.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CXCR4 | “In cancer, xanthohumol demonstrates remarkable efficacy by inhibiting tumor growth, angiogenesis, and metastasis through the suppression of critical pathways like CXCR4 and STAT3.” | 0.98 | hgnc_dict_v1 |
| phenotype | inflammatory bowel disease | “As a flavonoid, xanthohumol exhibits potent antioxidant and anti-inflammatory properties, making it effective in alleviating inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and inflammatory bowel disease.” | 0.98 | phenotype_alias_lexicon_v2 |
Comparative study of obeticholic acid and rosuvastatin in high-fat/fructose diet-induced metabolic dysfunction: role of AMPK, PPAR-γ, SREBP-1c, and STAT3 pathways.
PMID 41559213 | DOI 10.1007/s10735-025-10668-0 · Journal of molecular histology · 2026 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | STAT3 | “Comparative study of obeticholic acid and rosuvastatin in high-fat/fructose diet-induced metabolic dysfunction: role of AMPK, PPAR-γ, SREBP-1c, and STAT3 pathways.” | 0.98 | hgnc_dict_v1 |
| phenotype | metabolic syndrome | “Metabolic syndrome (MetS), often modeled by high-fat/fructose (HFF) diets, involves dyslipidemia, hypertension, insulin resistance, and liver dysfunction.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PCNA | “In addition to Liver and adipose tissue histopathology, area percentage of collagen fibers, adipocytes diameter, PPAR-γ, STAT3 and PCNA immunoexpression.” | 0.98 | hgnc_dict_v1 |
| phenotype | hypertension | “Metabolic syndrome (MetS), often modeled by high-fat/fructose (HFF) diets, involves dyslipidemia, hypertension, insulin resistance, and liver dysfunction.” | 0.98 | phenotype_alias_lexicon_v2 |
Modulation of Pulmonary Toxicity in Metabolic Syndrome Due to Variations in Iron Oxide Nanoparticle-Biocorona Composition.
PMID 35745361 | PMCID PMC9230893 | DOI 10.3390/nano12122022 · Nanomaterials (Basel, Switzerland) · 2022 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | STAT3 | “Western blot analysis revealed activation of STAT3, NF-κB, and ERK pathways due to the MetS-BC.” | 0.98 | hgnc_dict_v1 |
| phenotype | metabolic syndrome | “Modulation of Pulmonary Toxicity in Metabolic Syndrome Due to Variations in Iron Oxide Nanoparticle-Biocorona Composition.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CCL2 | “Macrophages exposed to Fe3O4 NPs with a MetS-BC for 1 h or 24 h at a concentration of 25 μg/mL demonstrated enhanced gene expression of inflammatory markers: CCL2, IL-6, and TNF-α compared to Fe3O4 NPs with a healthy BC.” | 0.98 | hgnc_dict_v1 |