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STAT6 and lung cancer are reported together in 1 article.
Gene
STAT6
- HGNC
- HGNC:11368
20articles
20mentions
3variants with confirmed gene link
Most co-reported phenotypes (articles)
asthma 4atopic dermatitis 2congenital myopathy 1epilepsy 1hearing loss 1lung cancer 1multiple sclerosis 1neurodevelopmental disorder 1
Reported variants (articles · ClinVar status)
Phenotype
Lung cancer
398articles
398mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Macrophages M2 polarization is involved in lapatinib-mediated chemopreventive effects in the lung cancer.
PMID 36931028 | DOI 10.1016/j.biopha.2023.114527 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | STAT6 | “Mechanistically, in our study, lapatinib inhibited IL-13 triggered STAT6 phosphorylation.” | 0.98 | hgnc_dict_v1 |
| phenotype | lung cancer | “Macrophages M2 polarization is involved in lapatinib-mediated chemopreventive effects in the lung cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CD163 | “In this research, we investigated that lapatinib could effectively suppress the expression of IL_13-induced M2 polarized macrophages surface markers i.e., CD163 and CD206, and downregulation of M2 genes such as Fizz1, Mrc1, Arg1, IL-10, Ym1, nd CCL2 in vitro.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “In this research, we investigated that lapatinib could effectively suppress the expression of IL_13-induced M2 polarized macrophages surface markers i.e., CD163 and CD206, and downregulation of M2 genes such as Fizz1, Mrc1, Arg1, IL-10, Ym1, nd CCL2 in vitro.” | 0.98 | hgnc_dict_v1 |