Advanced search
Combine gene, variant, phenotype, region and year filters
Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
Transparent by designEvery result links extracted entities to its source sentence and publication identifier.
Knowledge-base search
About your search
TCF7L2 and metabolic syndrome are reported together in 2 articles.
Gene
TCF7L2
- HGNC
- HGNC:11641
25articles
25mentions
4variants with confirmed gene link
Most co-reported phenotypes (articles)
diabetes mellitus 20obesity 5coronary artery disease 2metabolic syndrome 2breast cancer 1colorectal cancer 1dyslipidemia 1hepatocellular carcinoma 1
Reported variants (articles · ClinVar status)
Phenotype
Metabolic syndrome
141articles
141mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Interaction between the TCF7L2 gene and dietary intake on metabolic syndrome risk factors among Saudi Arabian adults.
PMID 40170676 | PMCID PMC11960299 | DOI 10.3389/fnut.2025.1513088 · Frontiers in nutrition · 2025 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TCF7L2 | “Interaction between the TCF7L2 gene and dietary intake on metabolic syndrome risk factors among Saudi Arabian adults.” | 0.98 | hgnc_dict_v1 |
| phenotype | metabolic syndrome | “Interaction between the TCF7L2 gene and dietary intake on metabolic syndrome risk factors among Saudi Arabian adults.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | obesity | “METHODS: This cross-sectional study included 271 adult participants (aged 20-55 years) of both genders with or without overweight or obesity (body mass index between 18-35 kg/m2).” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | diabetes mellitus | “INTRODUCTION: Transcription factor-7-like 2 (TCF7L2) is the most critical type 2 diabetes (T2D) gene identified to date.” | 0.93 | phenotype_alias_lexicon_v2 |
Associations of transcription factor 7-Like 2 (TCF7L2) gene polymorphism in patients of type 2 diabetes mellitus from Khyber Pakhtunkhwa population of Pakistan.
PMID 34394276 | PMCID PMC8356593 | DOI 10.4314/ahs.v21i1.4 · African health sciences · 2021 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TCF7L2 | “Associations of transcription factor 7-Like 2 (TCF7L2) gene polymorphism in patients of type 2 diabetes mellitus from Khyber Pakhtunkhwa population of Pakistan.” | 0.98 | hgnc_dict_v1 |
| phenotype | metabolic syndrome | “BACKGROUND: Type 2 diabetes mellitus (T2DM) is the most prevalent component of metabolic syndrome.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | diabetes mellitus | “Associations of transcription factor 7-Like 2 (TCF7L2) gene polymorphism in patients of type 2 diabetes mellitus from Khyber Pakhtunkhwa population of Pakistan.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs7903146 | “Genomic DNA was extracted and genotype of common variants (rs7903146 C/T and rs12255372 G/T) was carried out by amplification-refractory mutation system (ARMS)-PCR of sequence specific oligonucleotides.” | 0.90 | hgvs_regex_v1 |