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TERT and endometrial cancer are reported together in 2 articles.
Gene
TERT
- HGNC
- HGNC:11730
48articles
48mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
thyroid cancer 25breast cancer 2colorectal cancer 2diabetes mellitus 2endometrial cancer 2leukemia 2prostate cancer 2hypertension 1
Reported variants (articles · ClinVar status)
Phenotype
Endometrial cancer
49articles
49mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Telomerase reverse transcriptase promoter mutations in cancers derived from multiple organ sites among middle eastern population.
PMID 31669704 | DOI 10.1016/j.ygeno.2019.09.017 · Genomics · 2020 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TERT | “Sanger Sequencing and immunohistochemistry was employed to investigate the TERT promoter mutations and TERT protein expression with their association to clinicopathological characteristics in over 2200 samples of Middle Eastern origin from 13 different types of cancers.” | 0.98 | hgnc_dict_v1 |
| phenotype | endometrial cancer | “The TERT promoter mutations were most frequently present in bladder cancer (68.6%), followed by central nervous system tumors (28.7%), thyroid cancer (15.4%), prostate cancer (9.3%), endometrial carcinoma (3.7%), rhabdomyosarcoma (1.4%), colorectal cancer (1%), epithelial ovarian carcinoma (0.7%) and breast cancer (0.7%).” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | breast cancer | “The TERT promoter mutations were most frequently present in bladder cancer (68.6%), followed by central nervous system tumors (28.7%), thyroid cancer (15.4%), prostate cancer (9.3%), endometrial carcinoma (3.7%), rhabdomyosarcoma (1.4%), colorectal cancer (1%), epithelial ovarian carcinoma (0.7%) and breast cancer (0.7%).” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | colorectal cancer | “The TERT promoter mutations were most frequently present in bladder cancer (68.6%), followed by central nervous system tumors (28.7%), thyroid cancer (15.4%), prostate cancer (9.3%), endometrial carcinoma (3.7%), rhabdomyosarcoma (1.4%), colorectal cancer (1%), epithelial ovarian carcinoma (0.7%) and breast cancer (0.7%).” | 0.98 | phenotype_alias_lexicon_v2 |
Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.
PMID 26621817 | PMCID PMC4664893 | DOI 10.1038/srep17369 · Scientific reports · 2015 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TERT | “Using CRC and EC genome-wide association series, totalling 13,265 cancer cases and 40,245 controls, we found that the protective allele [G] at one previously-identified CRC polymorphism, rs2736100 near TERT, was associated with EC risk (odds ratio (OR) = 1.08, P = 0.000167); this polymorphism influences the risk of several other cancers.” | 0.98 | hgnc_dict_v1 |
| phenotype | endometrial cancer | “Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SH2B3 | “Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.” | 0.98 | hgnc_dict_v1 |
| gene | TSHZ1 | “Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.” | 0.98 | hgnc_dict_v1 |