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TERT and leukemia are reported together in 2 articles.
Gene
TERT
- HGNC
- HGNC:11730
48articles
48mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
thyroid cancer 25breast cancer 2colorectal cancer 2diabetes mellitus 2endometrial cancer 2leukemia 2prostate cancer 2hypertension 1
Reported variants (articles · ClinVar status)
Phenotype
Leukemia
652articles
652mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Transcriptomic Analysis of Conserved Telomere Maintenance Component 1 (CTC1) and Its Association with Leukemia.
PMID 36233645 | PMCID PMC9571731 | DOI 10.3390/jcm11195780 · Journal of clinical medicine · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TERT | “Telomere length (TEL) regulation is important for genome stability and is governed by the coordinated role of shelterin proteins, telomerase (TERT), and CST (CTC1/OBFC1/TEN1) complex.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “Transcriptomic Analysis of Conserved Telomere Maintenance Component 1 (CTC1) and Its Association with Leukemia.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CTC1 | “Transcriptomic Analysis of Conserved Telomere Maintenance Component 1 (CTC1) and Its Association with Leukemia.” | 0.98 | hgnc_dict_v1 |
| gene | TEN1 | “Telomere length (TEL) regulation is important for genome stability and is governed by the coordinated role of shelterin proteins, telomerase (TERT), and CST (CTC1/OBFC1/TEN1) complex.” | 0.98 | hgnc_dict_v1 |
Epithelial Cell Adhesion Molecule (EpCAM) Expression Can Be Modulated via NFκB.
PMID 36428553 | PMCID PMC9687693 | DOI 10.3390/biomedicines10112985 · Biomedicines · 2022 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TERT | “Expression of EpCAM and its downstream target genes (Myc and TERT) wasdownregulated upon treatment with costunolide in Jurkat cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “In the current research study, qPCR induced expression of EpCAM was noted in acute lymphoblastic leukemia (ALL) cases.” | 0.98 | phenotype_alias_lexicon_v2 |