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TFAM and obesity are reported together in 2 articles.

Gene

TFAM

17articles

17mentions

0variants with confirmed gene link

Most co-reported phenotypes (articles)

Phenotype

856articles

856mentions

12co-reported genes shown

Most co-reported genes (articles)

Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.

2 records shown · first 60

PMID 42051747 | PMCID PMC13112675 | DOI 10.3389/fphys.2026.1783080 · Frontiers in physiology · 2026 · 6 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	TFAM	“RESULTS AND DISCUSSION: Overfeeding increased body weight and induced lipid peroxidation and protein oxidation in both tissues, while genes related to mitochondrial dynamics (PGC1a and TFAM) were speci cally modulated, suggesting a targeted effect of uoxetine on mitochondrial biogenesis pathways by overfeeding across the tissues.”	0.98	hgnc_dict_v1
phenotype	obesity	“Modulation of the serotonergic system restores oxidative balance and gene expression in the brain and heart of rats with obesity induced by overnutrition.”	0.98	phenotype_alias_lexicon_v2
phenotype	hypertension	“INTRODUCTION: Studies have demonstrated that insults during development increase the risk for developing diseases later in life, including hypertension, ischemic heart disease, stroke, respiratory disease, diabetes, cancer, as well as psychiatric disorders.”	0.98	phenotype_alias_lexicon_v2
phenotype	stroke	“INTRODUCTION: Studies have demonstrated that insults during development increase the risk for developing diseases later in life, including hypertension, ischemic heart disease, stroke, respiratory disease, diabetes, cancer, as well as psychiatric disorders.”	0.98	phenotype_alias_lexicon_v2

PMID 39410930 | PMCID PMC11475474 | DOI 10.3389/fnut.2024.1409344 · Frontiers in nutrition · 2024 · 6 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	TFAM	“METHODS: The current study was designed to explore the effect of observing four-week, dawn to dusk IF by participants with obesity on gene expression of the anti-inflammatory CD163, oxidative stress, and bioenergetics enzymes (SOD2, Nrf2, and TFAM), as well as metabolic and cellular regulatory genes (SIRT1 and SIRT3).”	0.98	hgnc_dict_v1
phenotype	obesity	“Changes in haptoglobin genotype-based gene expressions upon the observance of dawn-to-dusk intermittent fasting: a prospective cohort study on overweight and obese individuals.”	0.93	phenotype_alias_lexicon_v2
gene	CD163	“METHODS: The current study was designed to explore the effect of observing four-week, dawn to dusk IF by participants with obesity on gene expression of the anti-inflammatory CD163, oxidative stress, and bioenergetics enzymes (SOD2, Nrf2, and TFAM), as well as metabolic and cellular regulatory genes (SIRT1 and SIRT3).”	0.98	hgnc_dict_v1
gene	SOD2	“METHODS: The current study was designed to explore the effect of observing four-week, dawn to dusk IF by participants with obesity on gene expression of the anti-inflammatory CD163, oxidative stress, and bioenergetics enzymes (SOD2, Nrf2, and TFAM), as well as metabolic and cellular regulatory genes (SIRT1 and SIRT3).”	0.98	hgnc_dict_v1