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TFAM and stroke are reported together in 1 article.
Gene
TFAM
- HGNC
- HGNC:11741
17articles
17mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Stroke
555articles
555mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Modulation of the serotonergic system restores oxidative balance and gene expression in the brain and heart of rats with obesity induced by overnutrition.
PMID 42051747 | PMCID PMC13112675 | DOI 10.3389/fphys.2026.1783080 · Frontiers in physiology · 2026 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TFAM | “RESULTS AND DISCUSSION: Overfeeding increased body weight and induced lipid peroxidation and protein oxidation in both tissues, while genes related to mitochondrial dynamics (PGC1a and TFAM) were speci cally modulated, suggesting a targeted effect of uoxetine on mitochondrial biogenesis pathways by overfeeding across the tissues.” | 0.98 | hgnc_dict_v1 |
| phenotype | stroke | “INTRODUCTION: Studies have demonstrated that insults during development increase the risk for developing diseases later in life, including hypertension, ischemic heart disease, stroke, respiratory disease, diabetes, cancer, as well as psychiatric disorders.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | obesity | “Modulation of the serotonergic system restores oxidative balance and gene expression in the brain and heart of rats with obesity induced by overnutrition.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | hypertension | “INTRODUCTION: Studies have demonstrated that insults during development increase the risk for developing diseases later in life, including hypertension, ischemic heart disease, stroke, respiratory disease, diabetes, cancer, as well as psychiatric disorders.” | 0.98 | phenotype_alias_lexicon_v2 |