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TG and breast cancer are reported together in 3 articles.
Gene
TG
- HGNC
- HGNC:11764
45articles
45mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Breast cancer
1,211articles
1,211mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Vitamin D-related genetic variants as predictive biomarkers for breast cancer in Jordanian women.
PMID 42292230 | PMCID PMC13253258 | DOI 10.3389/fmed.2026.1816935 · Frontiers in medicine · 2026 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TG | “RESULTS: Significant associations were observed for CYP2R1 rs12794714 and CYP27B1 rs10877012, with the GG genotype of CYP2R1 and the TG genotype of CYP27B1 associated with a reduced risk of breast cancer.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Vitamin D-related genetic variants as predictive biomarkers for breast cancer in Jordanian women.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CYP2R1 | “Variants in CYP2R1, CYP24A1, CYP27B1, and DBP have been reported to influence circulating 25(OH)D concentrations and provide evidence for a hypothesis that these polymorphisms may be associated with breast cancer risk by altering vitamin D metabolism and signaling.” | 0.98 | hgnc_dict_v1 |
| gene | CYP24A1 | “Variants in CYP2R1, CYP24A1, CYP27B1, and DBP have been reported to influence circulating 25(OH)D concentrations and provide evidence for a hypothesis that these polymorphisms may be associated with breast cancer risk by altering vitamin D metabolism and signaling.” | 0.98 | hgnc_dict_v1 |
Genomic Profiling of Thyroid Cancer Reveals a Role for Thyroglobulin in Metastasis.
PMID 27236916 | PMCID PMC4908175 | DOI 10.1016/j.ajhg.2016.04.014 · American journal of human genetics · 2016 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TG | “In addition to BRAF, N-RAS, and H-RAS, which have previously been shown to be recurrently mutated in PTC, our analysis highlights additional genes, including thyroglobulin (TG), which harbored somatic mutations in 3% of the entire cohort.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Papillary thyroid carcinoma (PTC) has a wide geographic variation in incidence; it is most common in Saudi Arabia, where it is only second to breast cancer as the most common cancer among females.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BRAF | “In addition to BRAF, N-RAS, and H-RAS, which have previously been shown to be recurrently mutated in PTC, our analysis highlights additional genes, including thyroglobulin (TG), which harbored somatic mutations in 3% of the entire cohort.” | 0.98 | hgnc_dict_v1 |
| phenotype | thyroid cancer | “Genomic Profiling of Thyroid Cancer Reveals a Role for Thyroglobulin in Metastasis.” | 0.98 | phenotype_alias_lexicon_v2 |
A single-nucleotide polymorphism in the TP53 and MDM-2 gene modifies breast cancer risk in an ethnic Arab population.
PMID 21477265 | DOI 10.1111/j.1472-8206.2011.00939.x · Fundamental & clinical pharmacology · 2012 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TG | “We found an increased breast cancer risk associated with the MDM2 GG [odds ratio (OR) = 2.79, 95% confidence interval (CI) = 2.04-3.92] and TG [OR = 1.43, 95% CI = 1.12-2.02] genotypes.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “A single-nucleotide polymorphism in the TP53 and MDM-2 gene modifies breast cancer risk in an ethnic Arab population.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TP53 | “A single-nucleotide polymorphism in the TP53 and MDM-2 gene modifies breast cancer risk in an ethnic Arab population.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “The tumor suppressor TP53 and its negative regulator MDM2 play crucial roles in carcinogenesis.” | 0.98 | hgnc_dict_v1 |