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TH and Parkinson disease are reported together in 3 articles.
Gene
TH
- HGNC
- HGNC:11782
5articles
5mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Parkinson disease
280articles
280mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Influence of serum concentration in retinoic acid and phorbol ester induced differentiation of SH-SY5Y human neuroblastoma cell line.
PMID 33098048 | DOI 10.1007/s11033-020-05925-2 · Molecular biology reports · 2020 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TH | “There was no significant difference in the expression of tyrosine hydroxylase (TH) gene between undifferentiated and differentiated SH-SY5Y cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | Parkinson disease | “In conclusion, to terminally differentiate SH-SY5Y cells to be used as a cell-based model to study Parkinson's disease (PD) to investigate molecular mechanisms and drug discovery, the optimal differentiation medium should contain 3% serum in RA-only.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | SNCA | “Cells differentiated with RA/TPA or RA differentiated showed increased production of the α-synuclein (SNCA) neuroprotein and dopamine neurotransmitter compared to undifferentiated cells, regardless serum concentrations used.” | 0.98 | hgnc_dict_v1 |
| gene | DRD2 | “However, the expression of dopamine receptor D2 (DRD2) gene was markedly increased (p<0.05) in differentiated cells with 3% serum and RA only when compared to undifferentiated cells.” | 0.98 | hgnc_dict_v1 |
Computational study of human tyrosine hydroxylase mutants to uphold [4-(Propan-2-yl) Phenyl]Carbamic acid as a potential inhibitor.
PMID 25230230 | DOI 10.2174/1871527313666140917111905 · CNS & neurological disorders drug targets · 2014 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TH | “It has been reported that a number of mutations in coding regions, splice sites and promoter regions of tyrosine hydroxylase (TH) are associated with many such diseases.” | 0.98 | hgnc_dict_v1 |
| phenotype | Parkinson disease | “Our results corroborate efficient binding of PPCA with normal and mutated TH, indicating that PPCA might be a strong therapeutic candidate for the management of Parkinson's disease and other related disorders.” | 0.93 | phenotype_alias_lexicon_v2 |
Targeting Parkinson's - tyrosine hydroxylase and oxidative stress as points of interventions.
PMID 22483312 | DOI 10.2174/187152712800792848 · CNS & neurological disorders drug targets · 2012 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TH | “In the present review, our focus was on recent advances in the treatment procedures of PD to achieve an increase in deficient tyrosine hydroxylase (TH) activity and/or expression.” | 0.98 | hgnc_dict_v1 |
| phenotype | Parkinson disease | “Parkinson's disease (PD) is characterized by the progressive loss of the dopaminergic neurons leading to decrease in striatal dopamine (DA) levels.” | 0.93 | phenotype_alias_lexicon_v2 |