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TLR2 and COVID-19 are reported together in 3 articles.
Gene
TLR2
- HGNC
- HGNC:11848
78articles
78mentions
9variants with confirmed gene link
Most co-reported phenotypes (articles)
obesity 4COVID-19 3breast cancer 3HIV infection 2asthma 2autism spectrum disorder 2colorectal cancer 2diabetes mellitus 2
Reported variants (articles · ClinVar status)
Phenotype
COVID-19
1,317articles
1,317mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Intrinsic factors behind long COVID: exploring the role of nucleocapsid protein in thrombosis.
PMID 40416618 | PMCID PMC12101441 | DOI 10.7717/peerj.19429 · PeerJ · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR2 | “Recent findings suggest that the NP acts as a pathogen-associated molecular pattern (PAMP) that binds to Toll-like receptor 2 (TLR2), activating NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) and MAPK (mitogen-activated protein kinase) signaling pathways.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “COVID-19, caused by the SARS-CoV-2, poses significant global health challenges.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | MERS | “While NPs from other coronaviruses, such as SARS-CoV and MERS-CoV, are known to increase inflammation and cause acute lung injury, the specific effects of the SARS-CoV-2 NP on host cells remain largely unexplored.” | 0.93 | phenotype_alias_lexicon_v2 |
Correlations between Kidney and Heart Function Bioindicators and the Expressions of Toll-Like, ACE2, and NRP-1 Receptors in COVID-19.
PMID 35891270 | PMCID PMC9319872 | DOI 10.3390/vaccines10071106 · Vaccines · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR2 | “AIM: This work aims to compare the changes in kidney and heart function bioindicators and expressions of TLRs (TLR2 and TLR2) as well as ACE2 and NRP-l receptors in moderate and severe COVID-19 patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “Correlations between Kidney and Heart Function Bioindicators and the Expressions of Toll-Like, ACE2, and NRP-1 Receptors in COVID-19.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ACE2 | “Correlations between Kidney and Heart Function Bioindicators and the Expressions of Toll-Like, ACE2, and NRP-1 Receptors in COVID-19.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “We measured the gene expression for Toll-Like Receptors (TLR2 and TLR4), ACE2, and NRP-1 in the blood samples using quantitative real-time PCR (qRT-PCR).” | 0.98 | hgnc_dict_v1 |
A Vaccine Construction against COVID-19-Associated Mucormycosis Contrived with Immunoinformatics-Based Scavenging of Potential Mucoralean Epitopes.
PMID 35632420 | PMCID PMC9147184 | DOI 10.3390/vaccines10050664 · Vaccines · 2022 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR2 | “Molecular interactions with major histocompatibility complex-1 (MHC-I), Toll-like receptors-2 (TLR2), and glucose-regulated protein 78 (GRP78), with scores of -896.0, -948.4, and -925.0, respectively, demonstrated its potential to bind with the human immune receptors.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “During the COVID-19 pandemic, the current wave of mucormycosis is a challenge to medical professionals as its effects are multiplied because of the severity of COVID-19 infection.” | 0.98 | phenotype_alias_lexicon_v2 |