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TLR2 and autism spectrum disorder are reported together in 2 articles.
Gene
TLR2
- HGNC
- HGNC:11848
78articles
78mentions
9variants with confirmed gene link
Most co-reported phenotypes (articles)
obesity 4COVID-19 3breast cancer 3HIV infection 2asthma 2autism spectrum disorder 2colorectal cancer 2diabetes mellitus 2
Reported variants (articles · ClinVar status)
Phenotype
Autism spectrum disorder
- HPO
- HP:0000729
881articles
881mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Resveratrol Improves Neuroimmune Dysregulation Through the Inhibition of Neuronal Toll-Like Receptors and COX-2 Signaling in BTBR T+ Itpr3tf/J Mice.
PMID 29468499 | DOI 10.1007/s12017-018-8483-0 · Neuromolecular medicine · 2018 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR2 | “We investigated the effect of resveratrol treatment on TLR2, TLR3, TLR4, NF-κB, and inducible nitric oxide synthase (iNOS or NOS2) levels in CD4 spleen cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | autism spectrum disorder | “Autism is a neurodevelopmental disorder characterized by deficits in qualitative impairments in communication, repetitive and social interaction, restricted, and stereotyped patterns of behavior.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | TLR4 | “Here, we explored whether resveratrol treatment decreases neuroimmune dysregulation mediated through toll-like receptor (TLR4) and nuclear factor-κB (NF-κB) signaling pathway in BTBR mice.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “We investigated the effect of resveratrol treatment on TLR2, TLR3, TLR4, NF-κB, and inducible nitric oxide synthase (iNOS or NOS2) levels in CD4 spleen cells.” | 0.98 | hgnc_dict_v1 |
Toll-like receptors, NF-κB, and IL-27 mediate adenosine A2A receptor signaling in BTBR T+ Itpr3tf/J mice.
PMID 28668513 | DOI 10.1016/j.pnpbp.2017.06.034 · Progress in neuro-psychopharmacology & biological psychiatry · 2017 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR2 | “Treatment of BTBR mice with SCH increased the percentage of splenic CD14+TLR2+ cells, CD14+TLR3+ cells, CD14+TLR4+ cells, and decreased the percentage of CD14+IL-27+ cells, as compared to the untreated BTBR mice.” | 0.98 | hgnc_dict_v1 |
| phenotype | autism spectrum disorder | “Autism is a predominant neurodevelopmental disorder characterized by impaired communication, social deficits, and repetitive behaviors.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CD14 | “Treatment of BTBR mice with SCH increased the percentage of splenic CD14+TLR2+ cells, CD14+TLR3+ cells, CD14+TLR4+ cells, and decreased the percentage of CD14+IL-27+ cells, as compared to the untreated BTBR mice.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Treatment of BTBR mice with SCH increased the percentage of splenic CD14+TLR2+ cells, CD14+TLR3+ cells, CD14+TLR4+ cells, and decreased the percentage of CD14+IL-27+ cells, as compared to the untreated BTBR mice.” | 0.98 | hgnc_dict_v1 |