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TLR2 and gastric cancer are reported together in 2 articles.
Gene
TLR2
- HGNC
- HGNC:11848
78articles
78mentions
9variants with confirmed gene link
Most co-reported phenotypes (articles)
obesity 4COVID-19 3breast cancer 3HIV infection 2asthma 2autism spectrum disorder 2colorectal cancer 2diabetes mellitus 2
Reported variants (articles · ClinVar status)
Phenotype
Gastric cancer
106articles
106mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Association of toll-like receptors 2, 4, 9 and 10 genes polymorphisms and Helicobacter pylori-related gastric diseases in Saudi patients.
PMID 32719215 | DOI 10.4103/ijmm.IJMM_20_164 · Indian journal of medical microbiology · 2020 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR2 | “MATERIALS AND METHODS: The association between the common single nucleotide polymorphisms (SNPs) in the genes of TLR2, 4, 9 and 10 and H. pylori-related gastric diseases were investigated by molecular methods after the confirmation of H. pylori infection.” | 0.98 | hgnc_dict_v1 |
| phenotype | gastric cancer | “The study included 210 patients in three groups; chronic gastritis (n = 90), peptic ulcer disease (PUD) (n = 75) and gastric carcinoma (n = 45).” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | TLR4 | “RESULTS: The results showed a significant association between TLR4 SNPs (rs 4986790 and rs 4986791) and the presence of H. pylori infection, especially in chronic gastritis patient group.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia | “Association of toll-like receptors 2, 4, 9 and 10 genes polymorphisms and Helicobacter pylori-related gastric diseases in Saudi patients. The study included 210 patients in three groups; chronic gastritis (n = 90), peptic ulcer disease (PUD) (n = 75) and gastric carcinoma (n = 45).” | 0.95 | saudi_context_rules_v1 |
Toll-like receptor gene polymorphisms and susceptibility to Epstein-Barr virus-associated and -negative gastric carcinoma in Northern China.
PMID 25843196 | PMCID PMC4392582 | DOI 10.4103/1319-3767.153832 · Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2015 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR2 | “PATIENTS AND METHODS: Polymorphisms of the TLR2, 3, 4, and 9 genes were measured in 52 cases of EBVaGC and 157 cases of EBV-negative GC (EBVnGC).” | 0.98 | hgnc_dict_v1 |
| phenotype | gastric cancer | “Toll-like receptor gene polymorphisms and susceptibility to Epstein-Barr virus-associated and -negative gastric carcinoma in Northern China.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | TLR3 | “As for the TLR3 gene (c.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “No SNPs single nucleotide polymorphisms (SNPs) were found in the TLR4 gene at the sites Asp299Gly and Thr399Ile.” | 0.98 | hgnc_dict_v1 |