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TLR2 and malaria are reported together in 2 articles.
Gene
TLR2
- HGNC
- HGNC:11848
78articles
78mentions
9variants with confirmed gene link
Most co-reported phenotypes (articles)
obesity 4COVID-19 3breast cancer 3HIV infection 2asthma 2autism spectrum disorder 2colorectal cancer 2diabetes mellitus 2
Reported variants (articles · ClinVar status)
Phenotype
Malaria
232articles
232mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula.
PMID 23289617 | DOI 10.1089/gtmb.2012.0281 · Genetic testing and molecular biomarkers · 2013 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR2 | “Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula.” | 0.98 | hgnc_dict_v1 |
| phenotype | malaria | “Considering the reported protective role of these polymorphisms against malaria, the data suggest that the regional variation at these gene loci could have been shaped by both evolutionary infection pressure and bidirectional human migrations in the past.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TLR4 | “Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia | “Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula. Two polymorphisms located in the TLR2 gene (Pro631His and Arg753Gln, rs5743704 and rs5743708, respectively), and two (Asp299Gly and Thr399Ile, rs4986790 and rs4986791, respectively), located in the TLR4 gene have been genotyped in 201 unrelated individuals from Saudi Arabia.” | 0.95 | saudi_context_rules_v1 |
Genome-wide screening identifies Plasmodium chabaudi-induced modifications of DNA methylation status of Tlr1 and Tlr6 gene promoters in liver, but not spleen, of female C57BL/6 mice.
PMID 23949311 | DOI 10.1007/s00436-013-3565-2 · Parasitology research · 2013 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR2 | “TLR6 and TLR1 are known as auxillary receptors to form heterodimers with TLR2 in plasma membranes of macrophages, which recognize different pathogen-associated molecular patterns (PAMPs), as, e.g., intact 3-acyl and sn-2-lyso-acyl glycosylphosphatidylinositols of P. falciparum, respectively.” | 0.98 | hgnc_dict_v1 |
| phenotype | malaria | “Epigenetic reprogramming of host genes via DNA methylation is increasingly recognized as critical for the outcome of diverse infectious diseases, but information for malaria is not yet available.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TLR6 | “TLR6 and TLR1 are known as auxillary receptors to form heterodimers with TLR2 in plasma membranes of macrophages, which recognize different pathogen-associated molecular patterns (PAMPs), as, e.g., intact 3-acyl and sn-2-lyso-acyl glycosylphosphatidylinositols of P. falciparum, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | TLR1 | “TLR6 and TLR1 are known as auxillary receptors to form heterodimers with TLR2 in plasma membranes of macrophages, which recognize different pathogen-associated molecular patterns (PAMPs), as, e.g., intact 3-acyl and sn-2-lyso-acyl glycosylphosphatidylinositols of P. falciparum, respectively.” | 0.98 | hgnc_dict_v1 |