Advanced search
Combine gene, variant, phenotype, region and year filters
Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
Transparent by designEvery result links extracted entities to its source sentence and publication identifier.
Knowledge-base search
About your search
TLR2 and obesity are reported together in 4 articles.
Gene
TLR2
- HGNC
- HGNC:11848
78articles
78mentions
9variants with confirmed gene link
Most co-reported phenotypes (articles)
obesity 4COVID-19 3breast cancer 3HIV infection 2asthma 2autism spectrum disorder 2colorectal cancer 2diabetes mellitus 2
Reported variants (articles · ClinVar status)
Phenotype
Obesity
- HPO
- HP:0001513
856articles
856mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
4 records shown · first 60Serum levels of Wnt5a in Egyptian women with obesity and their association with toll like receptor 2 Arg753Gln gene polymorphism in a pilot case control study of obesity as a state of metaflammation.
PMID 39837875 | PMCID PMC11751074 | DOI 10.1038/s41598-025-85470-9 · Scientific reports · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR2 | “We aimed to assess the serum levels of wingless integration site family member 5 A (Wnt5a), leptin, and tumor necrosis factor-alpha (TNF-α) as markers of obesity-associated metaflammation and investigate the association with toll-like receptors2 (TLR2) gene (Arg753Gln) single nucleotide polymorphism (SNP) among Egyptian females.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Serum levels of Wnt5a in Egyptian women with obesity and their association with toll like receptor 2 Arg753Gln gene polymorphism in a pilot case control study of obesity as a state of metaflammation.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | metabolic syndrome | “Only TNF-α and leptin were associated with metabolic syndrome (MetS) among the obesity group.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs5743708 | “No significant differences were found in the distribution of TLR2 Arg753Gln (rs5743708) genotypes and alleles according to obesity or MetS, and the regression analysis showed no significant risk association.” | 0.90 | hgvs_regex_v1 |
A study on the immunological vitality of an inflammatory biomarker explored with rs5743708 polymorphism in TLR2 gene among Saudi women confirmed with polycystic ovarian syndrome.
PMID 37485450 | PMCID PMC10362453 | DOI 10.1016/j.sjbs.2023.103687 · Saudi journal of biological sciences · 2023 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR2 | “A study on the immunological vitality of an inflammatory biomarker explored with rs5743708 polymorphism in TLR2 gene among Saudi women confirmed with polycystic ovarian syndrome.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Toll-like receptor 2 (TLR2) gene was linked to PCOS and chronic inflammation, and the prevalence of obesity was rising in Saudi women.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “A study on the immunological vitality of an inflammatory biomarker explored with rs5743708 polymorphism in TLR2 gene among Saudi women confirmed with polycystic ovarian syndrome. Toll-like receptor 2 (TLR2) gene was linked to PCOS and chronic inflammation, and the prevalence of obesity was rising in Saudi women. AIM: In this study, we investigated the molecular role of rs5743708 polymorphism in TLR2 gene among Saudi women diagnosed with PCOS using the Rotterdam criteria. METHODS: Blood samples were collected from 220 Saudi women in this hospital-based case-control study; 110 were PCOS women and remaining 110 were non-PCOS (control women). CONCLUSION: The rs5743708 polymorphism was not associated to PCOS in Saudi women.” | 0.95 | saudi_context_rules_v1 |
| variant | rs5743708 | “A study on the immunological vitality of an inflammatory biomarker explored with rs5743708 polymorphism in TLR2 gene among Saudi women confirmed with polycystic ovarian syndrome.” | 0.90 | hgvs_regex_v1 |
Expression of Steroid Receptor RNA Activator 1 (SRA1) in the Adipose Tissue Is Associated with TLRs and IRFs in Diabesity.
PMID 36552771 | PMCID PMC9776802 | DOI 10.3390/cells11244007 · Cells · 2022 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR2 | “SRA1 expression associated with TLR2, IRAK1, and IRF3 expression only in individuals with obesity, regardless of diabetes status.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Steroid receptor RNA activator gene (SRA1) emerges as a player in pathophysiological responses of adipose tissue (AT) in metabolic disorders such as obesity and type 2 diabetes (T2D).” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SRA1 | “Expression of Steroid Receptor RNA Activator 1 (SRA1) in the Adipose Tissue Is Associated with TLRs and IRFs in Diabesity.” | 0.98 | hgnc_dict_v1 |
| gene | IRAK1 | “The gene expression of SRA1, TLRs-2,3,4,7,8,9,10 and their downstream signaling mediators including IRFs-3,4,5, myeloid differentiation factor 88 (MyD88), interleukin-1 receptor-associated kinase 1 (IRAK1), and nuclear factor-κB (NF-κB) were determined using qRT-PCR and SRA1 protein expression was determined by immunohistochemistry.” | 0.98 | hgnc_dict_v1 |
Deletion of Thioredoxin-interacting protein ameliorates high fat diet-induced non-alcoholic steatohepatitis through modulation of Toll-like receptor 2-NLRP3-inflammasome axis: Histological and immunohistochemical study.
PMID 29482933 | DOI 10.1016/j.acthis.2018.02.006 · Acta histochemica · 2018 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR2 | “Toll-like receptor2 (TLR2) and Nod-like receptor protein 3 (NLRP3) Inflammasome are implicated in hepatic steatosis, inflammation and fibrosis; the histological landmark stages of NASH.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Endemic prevalence of obesity is associated with alarming increases in non-alcoholic steatohepatitis (NASH) with limited available therapeutics.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | NLRP3 | “Toll-like receptor2 (TLR2) and Nod-like receptor protein 3 (NLRP3) Inflammasome are implicated in hepatic steatosis, inflammation and fibrosis; the histological landmark stages of NASH.” | 0.98 | hgnc_dict_v1 |
| gene | TXNIP | “TXNIP, a member of α-arrestin family activates NLRP3 in response to various danger stimuli.” | 0.98 | hgnc_dict_v1 |