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TLR3 and COVID-19 are reported together in 3 articles.
Gene
TLR3
- HGNC
- HGNC:11849
43articles
43mentions
10variants with confirmed gene link (top 10)
Most co-reported phenotypes (articles)
COVID-19 3hepatitis B 3hepatitis C 3hepatocellular carcinoma 3HIV infection 2autism spectrum disorder 2neurodevelopmental disorder 2tuberculosis 2
Reported variants (articles · ClinVar status)
Phenotype
COVID-19
1,317articles
1,317mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Multiple inborn errors of type I IFN immunity in a 33-year-old male with a fatal case of COVID-19.
PMID 38665565 | PMCID PMC11043952 | DOI 10.1016/j.heliyon.2024.e29338 · Heliyon · 2024 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR3 | “The three mutations were predicted to predispose to severe viral infections: monoallelic R488X TLR3, monoallelic His684Arg TLR3, and biallelic Val363Met IRF3.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “Multiple inborn errors of type I IFN immunity in a 33-year-old male with a fatal case of COVID-19.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | IRF3 | “The three mutations were predicted to predispose to severe viral infections: monoallelic R488X TLR3, monoallelic His684Arg TLR3, and biallelic Val363Met IRF3.” | 0.98 | hgnc_dict_v1 |
| variant | R488X | “The three mutations were predicted to predispose to severe viral infections: monoallelic R488X TLR3, monoallelic His684Arg TLR3, and biallelic Val363Met IRF3.” | 0.82 | literature_variant_regex_v2 |
Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective.
PMID 32599245 | PMCID PMC7319641 | DOI 10.1016/j.ijbiomac.2020.06.228 · International journal of biological macromolecules · 2020 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR3 | “We have identified significant interaction between ISGs and TLR3 agonists, like poly I: C, and imiquimod, and suggests that TLR3 agonists can be considered as a potential drug for drug repurposing in COVID-19.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | IFIT1 | “These ISGs (IFIT1, IFITM1, IRF7, ISG15, MX1, and OAS2) can be considered as potential candidates for drug targets in the treatments of COVID-19.” | 0.98 | hgnc_dict_v1 |
| gene | IFITM1 | “These ISGs (IFIT1, IFITM1, IRF7, ISG15, MX1, and OAS2) can be considered as potential candidates for drug targets in the treatments of COVID-19.” | 0.98 | hgnc_dict_v1 |
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
PMID 32972995 | PMCID PMC7857407 | DOI 10.1126/science.abd4570 · Science (New York, N.Y.) · 2020 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR3 | “We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I interferon (IFN) immunity to influenza virus in 659 patients with life-threatening COVID-19 pneumonia relative to 534 subjects with asymptomatic or benign infection.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | IRF7 | “We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I interferon (IFN) immunity to influenza virus in 659 patients with life-threatening COVID-19 pneumonia relative to 534 subjects with asymptomatic or benign infection.” | 0.98 | hgnc_dict_v1 |
| phenotype | SARS | “Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19).” | 0.93 | phenotype_alias_lexicon_v2 |