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TLR3 and SARS are reported together in 1 article.
Gene
TLR3
- HGNC
- HGNC:11849
43articles
43mentions
10variants with confirmed gene link (top 10)
Most co-reported phenotypes (articles)
COVID-19 3hepatitis B 3hepatitis C 3hepatocellular carcinoma 3HIV infection 2autism spectrum disorder 2neurodevelopmental disorder 2tuberculosis 2
Reported variants (articles · ClinVar status)
Phenotype
SARS
347articles
347mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
PMID 32972995 | PMCID PMC7857407 | DOI 10.1126/science.abd4570 · Science (New York, N.Y.) · 2020 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR3 | “We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I interferon (IFN) immunity to influenza virus in 659 patients with life-threatening COVID-19 pneumonia relative to 534 subjects with asymptomatic or benign infection.” | 0.98 | hgnc_dict_v1 |
| phenotype | SARS | “Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19).” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | IRF7 | “We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I interferon (IFN) immunity to influenza virus in 659 patients with life-threatening COVID-19 pneumonia relative to 534 subjects with asymptomatic or benign infection.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.” | 0.98 | phenotype_alias_lexicon_v2 |